tetano
Editor, Senior Moderator
Expert Rev Vaccines
. 2022 Aug 19.
doi: 10.1080/14760584.2022.2115362. Online ahead of print.
Adjuvanted versus non-adjuvanted standard-dose influenza vaccines in preventing all-cause hospitalizations in the elderly: a cohort study with nested case-control analyses over 18 influenza seasons
Francesco Lapi[SUP] 1 [/SUP], Alexander Domnich[SUP] 2 [/SUP], Ettore Marconi[SUP] 1 [/SUP], Alessandro Rossi[SUP] 3 [/SUP], Claudio Cricelli[SUP] 3 [/SUP]
Affiliations
Abstract
Background: The higher effectiveness of adjuvanted trivalent influenza vaccine (aTIV) versus non-adjuvanted (na) formulations in preventing all-cause hospitalization has been demonstrated for a single influenza season and in institutionalized elderly only. This study evaluated the relative vaccine effectiveness for aTIV vs. non-adjuvanted trivalent (naTIV) and/or quadrivalent (naQIV) influenza vaccines in preventing all-cause hospitalizations across 18 influenza seasons in primary care.
Research design and methods: Using Health Search Database, a nested case-control analysis was conducted in a cohort of older adults being vaccinated with aTIV or naTIV/naQIV. Conditional logistic regression was adopted to estimate the odds ratio (OR) of all-cause hospitalizations occurred during the epidemic period.
Results: Of 58,252 patients vaccinated with aTIV and naTIV/naQIV for the first time, 2,504 cases of all-cause hospitalization (3.46 per 1,000 person-weeks) during the 18 influenza seasons were identified. Compared with naTIV/naQIV, aTIV was associated with a 12% reduced the odds of all-cause hospitalizations (OR 0.88; 95% CI: 0.80-0.98).
Conclusions: In an 18-season cohort of older adults, aTIV reduced the risk of all-cause hospitalizations when compared with naTIV/naQIV. Our findings confirm additional benefits for adjuvanted influenza vaccines in older adults.
Keywords: Nested Case-Control Studies; all-cause hospitalization; influenza vaccine; older adults; primary care.
. 2022 Aug 19.
doi: 10.1080/14760584.2022.2115362. Online ahead of print.
Adjuvanted versus non-adjuvanted standard-dose influenza vaccines in preventing all-cause hospitalizations in the elderly: a cohort study with nested case-control analyses over 18 influenza seasons
Francesco Lapi[SUP] 1 [/SUP], Alexander Domnich[SUP] 2 [/SUP], Ettore Marconi[SUP] 1 [/SUP], Alessandro Rossi[SUP] 3 [/SUP], Claudio Cricelli[SUP] 3 [/SUP]
Affiliations
- PMID: 35984048
- DOI: 10.1080/14760584.2022.2115362
Abstract
Background: The higher effectiveness of adjuvanted trivalent influenza vaccine (aTIV) versus non-adjuvanted (na) formulations in preventing all-cause hospitalization has been demonstrated for a single influenza season and in institutionalized elderly only. This study evaluated the relative vaccine effectiveness for aTIV vs. non-adjuvanted trivalent (naTIV) and/or quadrivalent (naQIV) influenza vaccines in preventing all-cause hospitalizations across 18 influenza seasons in primary care.
Research design and methods: Using Health Search Database, a nested case-control analysis was conducted in a cohort of older adults being vaccinated with aTIV or naTIV/naQIV. Conditional logistic regression was adopted to estimate the odds ratio (OR) of all-cause hospitalizations occurred during the epidemic period.
Results: Of 58,252 patients vaccinated with aTIV and naTIV/naQIV for the first time, 2,504 cases of all-cause hospitalization (3.46 per 1,000 person-weeks) during the 18 influenza seasons were identified. Compared with naTIV/naQIV, aTIV was associated with a 12% reduced the odds of all-cause hospitalizations (OR 0.88; 95% CI: 0.80-0.98).
Conclusions: In an 18-season cohort of older adults, aTIV reduced the risk of all-cause hospitalizations when compared with naTIV/naQIV. Our findings confirm additional benefits for adjuvanted influenza vaccines in older adults.
Keywords: Nested Case-Control Studies; all-cause hospitalization; influenza vaccine; older adults; primary care.