tetano
Editor, Senior Moderator
Expert Rev Vaccines
. 2023 Oct 19.
doi: 10.1080/14760584.2023.2272655. Online ahead of print. Immune response and safety of inactivated SARS-CoV-2 vaccines during pregnancy: a real-world observational study
Yajie Gong[SUP] 1 2 [/SUP], Xi Zhang[SUP] 1 2 [/SUP], Xue Han[SUP] 1 2 [/SUP], Baolan Chen[SUP] 1 2 3 [/SUP], Yingxia Xu[SUP] 1 2 3 [/SUP], Jitian Huang[SUP] 1 2 3 [/SUP], Wenhan Yang[SUP] 1 3 [/SUP], Xi Fu[SUP] 1 3 [/SUP], Qiancui Wang[SUP] 4 [/SUP], Zhongjun Li[SUP] 5 [/SUP], Chunfeng Wu[SUP] 6 [/SUP], Tianran Shen[SUP] 1 3 [/SUP], Yuting Fan[SUP] 1 2 3 [/SUP], Yingshi Dai[SUP] 1 2 3 [/SUP], Yaping Qiao[SUP] 7 [/SUP], Gang Zeng[SUP] 7 [/SUP], Jikai Zhang[SUP] 8 [/SUP], Qingsong Chen[SUP] 1 2 3 [/SUP]
Affiliations
Background: As pregnant women are excluded from clinical trials of inactivated SARS-CoV-2 vaccines, it is important to assess the immune response in women receiving the vaccination while unknowingly pregnant.
Methods: In a multicenter cross-sectional study, we enrolled 873 pregnant women aged 18-45 years. Serum antibody levels induced by inactivated vaccines were determined. Adverse events were collected by self-reported survey after vaccination. Logistic regression model and restricted cubic spline model were used to investigate the association of factors with antibody positivity.
Results: As the doses of the vaccine increase, neutralizing antibody (NAb) positivity was 98.3%, 39.5%, and 9.5% in pregnant women, respectively. The dose of vaccine and duration since vaccination were associated with NAb positivity. The OR of two and three doses of vaccines were 7.20 and 458.33 (P < 0.05). NAb levels and duration since vaccination showed a linear relationship in pregnant women vaccinated two doses, with a decrease to a near seropositivity threshold at 22 weeks. Adverse events were mainly mild or moderate after vaccinated during pregnancy, with no increase in incidence compared with whom vaccinated during pre-pregnancy.
Conclusions: The use of inactivated vaccines during pregnancy induced favorable immune persistence, and the incidence of adverse events did not increase.
Keywords: Coronavirus disease 2019 (COVID-19); immune response; inactivated vaccine; pregnancy; safety.
. 2023 Oct 19.
doi: 10.1080/14760584.2023.2272655. Online ahead of print. Immune response and safety of inactivated SARS-CoV-2 vaccines during pregnancy: a real-world observational study
Yajie Gong[SUP] 1 2 [/SUP], Xi Zhang[SUP] 1 2 [/SUP], Xue Han[SUP] 1 2 [/SUP], Baolan Chen[SUP] 1 2 3 [/SUP], Yingxia Xu[SUP] 1 2 3 [/SUP], Jitian Huang[SUP] 1 2 3 [/SUP], Wenhan Yang[SUP] 1 3 [/SUP], Xi Fu[SUP] 1 3 [/SUP], Qiancui Wang[SUP] 4 [/SUP], Zhongjun Li[SUP] 5 [/SUP], Chunfeng Wu[SUP] 6 [/SUP], Tianran Shen[SUP] 1 3 [/SUP], Yuting Fan[SUP] 1 2 3 [/SUP], Yingshi Dai[SUP] 1 2 3 [/SUP], Yaping Qiao[SUP] 7 [/SUP], Gang Zeng[SUP] 7 [/SUP], Jikai Zhang[SUP] 8 [/SUP], Qingsong Chen[SUP] 1 2 3 [/SUP]
Affiliations
- PMID: 37855091
- DOI: 10.1080/14760584.2023.2272655
Background: As pregnant women are excluded from clinical trials of inactivated SARS-CoV-2 vaccines, it is important to assess the immune response in women receiving the vaccination while unknowingly pregnant.
Methods: In a multicenter cross-sectional study, we enrolled 873 pregnant women aged 18-45 years. Serum antibody levels induced by inactivated vaccines were determined. Adverse events were collected by self-reported survey after vaccination. Logistic regression model and restricted cubic spline model were used to investigate the association of factors with antibody positivity.
Results: As the doses of the vaccine increase, neutralizing antibody (NAb) positivity was 98.3%, 39.5%, and 9.5% in pregnant women, respectively. The dose of vaccine and duration since vaccination were associated with NAb positivity. The OR of two and three doses of vaccines were 7.20 and 458.33 (P < 0.05). NAb levels and duration since vaccination showed a linear relationship in pregnant women vaccinated two doses, with a decrease to a near seropositivity threshold at 22 weeks. Adverse events were mainly mild or moderate after vaccinated during pregnancy, with no increase in incidence compared with whom vaccinated during pre-pregnancy.
Conclusions: The use of inactivated vaccines during pregnancy induced favorable immune persistence, and the incidence of adverse events did not increase.
Keywords: Coronavirus disease 2019 (COVID-19); immune response; inactivated vaccine; pregnancy; safety.