tetano
Editor, Senior Moderator
Expert Rev Vaccines
. 2025 Jul 23.
doi: 10.1080/14760584.2025.2536087. Online ahead of print. Real-world effectiveness of live attenuated influenza vaccines (LAIV) and inactivated influenza vaccines (IIV) in children from 2003 to 2023: a systematic literature review and network meta-analysis
Anke L Stuurman[SUP] 1 [/SUP], Joshua Enxing[SUP] 2 [/SUP], Aura V Gutiérrez[SUP] 1 [/SUP], Christen M Gray[SUP] 2 [/SUP], Ingrid T Sepúlveda-Pachón[SUP] 1 [/SUP], Egbe Ubamadu[SUP] 1 [/SUP], Allyn Bandell[SUP] 3 [/SUP], Sylvia Taylor[SUP] 4 [/SUP], Georges El Azzi[SUP] 4 [/SUP], Wilhelmine Meeraus[SUP] 5 [/SUP]
Affiliations
Introduction: Circulating influenza strains, vaccine effectiveness (VE), and vaccine recommendations vary over time. A systematic literature review (SLR), random effects meta-analysis (REMA), and network meta-analysis (NMA) estimated absolute VE (aVE) and relative VE (rVE) of LAIV and IIV in children/adolescents from initial LAIV approval in 2003.
Methods: Northern Hemisphere studies (2003-2023) with children ≤19 yrs were included. A modified Newcastle-Ottawa Scale assessed risk-of-bias. REMA estimated aVE and three-node NMA (LAIV-IIV-unvaccinated) estimated rVE over three periods: 2003-04 to 2008-09 (pre-2009 A(H1N1) pandemic); 2010-11 to 2016-17 (post-2009 pandemic); 2017-18 to 2022-23 (post-LAIV strain-selection optimization).
Results: 109 studies included. aVE of LAIV and IIV against any influenza was similar (~50%) in each period. Effectiveness of LAIV vs. IIV against influenza types/subtypes was comparable except: (1) greater effectiveness with IIV for A(H1N1) in 2010-11 to 2016-17 (rVE -46% [95% CI: -57, -33]); (2) greater effectiveness with LAIV for influenza B in 2017-18 to 2022-23 (rVE 196% [95% CI: 73, 406]). In 2017-18 to 2022-23, effectiveness of LAIV and IIV against A(H1N1) was similar (rVE 10% [95% CI: -35, 87]).
Conclusions: LAIV and IIV have demonstrated comparable effectiveness against any influenza in children.
Keywords: A(H1N1); inactivated influenza vaccine; influenza; live attenuated influenza vaccine; vaccine effectiveness.
. 2025 Jul 23.
doi: 10.1080/14760584.2025.2536087. Online ahead of print. Real-world effectiveness of live attenuated influenza vaccines (LAIV) and inactivated influenza vaccines (IIV) in children from 2003 to 2023: a systematic literature review and network meta-analysis
Anke L Stuurman[SUP] 1 [/SUP], Joshua Enxing[SUP] 2 [/SUP], Aura V Gutiérrez[SUP] 1 [/SUP], Christen M Gray[SUP] 2 [/SUP], Ingrid T Sepúlveda-Pachón[SUP] 1 [/SUP], Egbe Ubamadu[SUP] 1 [/SUP], Allyn Bandell[SUP] 3 [/SUP], Sylvia Taylor[SUP] 4 [/SUP], Georges El Azzi[SUP] 4 [/SUP], Wilhelmine Meeraus[SUP] 5 [/SUP]
Affiliations
- PMID: 40697050
- DOI: 10.1080/14760584.2025.2536087
Introduction: Circulating influenza strains, vaccine effectiveness (VE), and vaccine recommendations vary over time. A systematic literature review (SLR), random effects meta-analysis (REMA), and network meta-analysis (NMA) estimated absolute VE (aVE) and relative VE (rVE) of LAIV and IIV in children/adolescents from initial LAIV approval in 2003.
Methods: Northern Hemisphere studies (2003-2023) with children ≤19 yrs were included. A modified Newcastle-Ottawa Scale assessed risk-of-bias. REMA estimated aVE and three-node NMA (LAIV-IIV-unvaccinated) estimated rVE over three periods: 2003-04 to 2008-09 (pre-2009 A(H1N1) pandemic); 2010-11 to 2016-17 (post-2009 pandemic); 2017-18 to 2022-23 (post-LAIV strain-selection optimization).
Results: 109 studies included. aVE of LAIV and IIV against any influenza was similar (~50%) in each period. Effectiveness of LAIV vs. IIV against influenza types/subtypes was comparable except: (1) greater effectiveness with IIV for A(H1N1) in 2010-11 to 2016-17 (rVE -46% [95% CI: -57, -33]); (2) greater effectiveness with LAIV for influenza B in 2017-18 to 2022-23 (rVE 196% [95% CI: 73, 406]). In 2017-18 to 2022-23, effectiveness of LAIV and IIV against A(H1N1) was similar (rVE 10% [95% CI: -35, 87]).
Conclusions: LAIV and IIV have demonstrated comparable effectiveness against any influenza in children.
Keywords: A(H1N1); inactivated influenza vaccine; influenza; live attenuated influenza vaccine; vaccine effectiveness.