tetano
Editor, Senior Moderator
Pediatr Int. 2010 Dec 30. doi: 10.1111/j.1442-200X.2010.03319.x. [Epub ahead of print]
Factors Associated with Hypoxemia in Children Infected with Pandemic H1N1 2009 Influenza Virus.
Yeom JS, Park JS, Seo JH, Park ES, Lim JY, Park CH, Woo HO, Youn HS, Cho JM.
Department of Pediatric and Department of Radiology, Gyeongsang National University School of Medicine, Jinju, Korea.
Abstract
Background: Hypoxemia was found to be a major cause of death from pandemic H1N1 2009 influenza (pH1N1) infection. There is limited data on factors associated with hypoxemia in children infected with pH1N1 influenza virus. Methods: We investigated factors associated with hypoxemia using univariate and multivariate analyses in 76 hospitalized pediatric patients with laboratory-confirmed H1N1 influenza virus infection at Gyeongsang National University Hospital in Jinju, South Korea, from August 2009 to January 2010 by retrospective chart review. Results and Conclusions: Hypoxemia occurred in 17 children (22%), of which 3 were admitted to an intensive care unit and 1 died. Hypoxemic patients were significantly more likely to have a higher respiratory rate, pulse rate, white blood cell count (WBC), and C-reactive protein level, as well as a longer hospital stay. Respiratory rate and WBC count at admission were independently associated with hypoxemia as determined by multivariate analyses, and this association was found to be clinically significant. Although a higher WBC count and respiratory rate may not be specific for pHINI but represent the degree of disease severity for any infectious respiratory disease in general, clinicians can use these parameters at admission as useful, early indicators of disease severity in pediatric pH1N1 infection.
? 2010 The Authors. Pediatrics International ? 2010 Japan Pediatric Society.
PMID: 21199168 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21199168
Factors Associated with Hypoxemia in Children Infected with Pandemic H1N1 2009 Influenza Virus.
Yeom JS, Park JS, Seo JH, Park ES, Lim JY, Park CH, Woo HO, Youn HS, Cho JM.
Department of Pediatric and Department of Radiology, Gyeongsang National University School of Medicine, Jinju, Korea.
Abstract
Background: Hypoxemia was found to be a major cause of death from pandemic H1N1 2009 influenza (pH1N1) infection. There is limited data on factors associated with hypoxemia in children infected with pH1N1 influenza virus. Methods: We investigated factors associated with hypoxemia using univariate and multivariate analyses in 76 hospitalized pediatric patients with laboratory-confirmed H1N1 influenza virus infection at Gyeongsang National University Hospital in Jinju, South Korea, from August 2009 to January 2010 by retrospective chart review. Results and Conclusions: Hypoxemia occurred in 17 children (22%), of which 3 were admitted to an intensive care unit and 1 died. Hypoxemic patients were significantly more likely to have a higher respiratory rate, pulse rate, white blood cell count (WBC), and C-reactive protein level, as well as a longer hospital stay. Respiratory rate and WBC count at admission were independently associated with hypoxemia as determined by multivariate analyses, and this association was found to be clinically significant. Although a higher WBC count and respiratory rate may not be specific for pHINI but represent the degree of disease severity for any infectious respiratory disease in general, clinicians can use these parameters at admission as useful, early indicators of disease severity in pediatric pH1N1 infection.
? 2010 The Authors. Pediatrics International ? 2010 Japan Pediatric Society.
PMID: 21199168 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21199168