tetano
Editor, Senior Moderator
Front Cell Infect Microbiol
. 2024 Mar 28:14:1355809.
doi: 10.3389/fcimb.2024.1355809. eCollection 2024. ACE2 and TMPRSS2 expression in patients before, during, and after SARS-CoV-2 infection
Henrique Borges da Silva Grisard[SUP] 1 2 3 [/SUP], Marcos André Schörner[SUP] 1 [/SUP], Fernando Hartmann Barazzetti[SUP] 1 2 3 [/SUP], Julia Kinetz Wachter[SUP] 1 4 [/SUP], Manoela Valmorbida[SUP] 1 [/SUP], Glauber Wagner[SUP] 2 3 [/SUP], Gislaine Fongaro[SUP] 3 5 [/SUP], Maria Luiza Bazzo[SUP] 1 4 [/SUP]
Affiliations
During the SARS-CoV-2 pandemic angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) were constantly under the scientific spotlight, but most studies evaluated ACE2 and TMPRSS2 expression levels in patients infected by SARS-CoV-2. Thus, this study aimed to evaluate the expression levels of both proteins before, during, and after-infection. For that, nasopharyngeal samples from 26 patients were used to measure ACE2/TMPRSS2 ex-pression via qPCR. Symptomatic patients presented lower ACE2 expression levels before and after the infection than those in asymptomatic patients; however, these levels increased during SARS-CoV-2 infection. In addition, symptomatic patients presented higher expression levels of TMPRSS2 pre-infection, which decreased in the following periods. In summary, ACE2 and TMPRSS2 expression levels are potential risk factors for the development of symptomatic COVID-19, and the presence of SARS-CoV-2 potentially modulates those levels.
Keywords: ACE2; SARS-CoV-2; TMPRSS2; host-parasite; pathogenicity.
. 2024 Mar 28:14:1355809.
doi: 10.3389/fcimb.2024.1355809. eCollection 2024. ACE2 and TMPRSS2 expression in patients before, during, and after SARS-CoV-2 infection
Henrique Borges da Silva Grisard[SUP] 1 2 3 [/SUP], Marcos André Schörner[SUP] 1 [/SUP], Fernando Hartmann Barazzetti[SUP] 1 2 3 [/SUP], Julia Kinetz Wachter[SUP] 1 4 [/SUP], Manoela Valmorbida[SUP] 1 [/SUP], Glauber Wagner[SUP] 2 3 [/SUP], Gislaine Fongaro[SUP] 3 5 [/SUP], Maria Luiza Bazzo[SUP] 1 4 [/SUP]
Affiliations
- PMID: 38606293
- PMCID: PMC11007167
- DOI: 10.3389/fcimb.2024.1355809
During the SARS-CoV-2 pandemic angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) were constantly under the scientific spotlight, but most studies evaluated ACE2 and TMPRSS2 expression levels in patients infected by SARS-CoV-2. Thus, this study aimed to evaluate the expression levels of both proteins before, during, and after-infection. For that, nasopharyngeal samples from 26 patients were used to measure ACE2/TMPRSS2 ex-pression via qPCR. Symptomatic patients presented lower ACE2 expression levels before and after the infection than those in asymptomatic patients; however, these levels increased during SARS-CoV-2 infection. In addition, symptomatic patients presented higher expression levels of TMPRSS2 pre-infection, which decreased in the following periods. In summary, ACE2 and TMPRSS2 expression levels are potential risk factors for the development of symptomatic COVID-19, and the presence of SARS-CoV-2 potentially modulates those levels.
Keywords: ACE2; SARS-CoV-2; TMPRSS2; host-parasite; pathogenicity.