tetano
Editor, Senior Moderator
Front Endocrinol (Lausanne)
. 2023 Apr 4;14:1168927.
doi: 10.3389/fendo.2023.1168927. eCollection 2023.
Case report: Fulminant type 1 diabetes following paucisymptomatic SARS-CoV-2 infection during late pregnancy
Lingling Zhou[SUP] 1 [/SUP], Huanjia Qu[SUP] 1 [/SUP], Qiuling Zhang[SUP] 1 [/SUP], Jinhua Hu[SUP] 1 [/SUP], Lan Shou[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Dysregulation of glucose metabolism has been linked to SARS-CoV-2 infection. In addition, the occurrence of new onset diabetes mellitus, including fulminant type 1 diabetes, has been reported after SARS-CoV-2 infection or vaccination.
Methods and results: A young Chinese woman in her last trimester of pregnancy presented with an abrupt progression of hyperglycemia and ketoacidosis, but with a near-normal glycohemoglobin level following paucisymptomatic SARS-CoV-2 infection. The low C peptide levels, both fasting and postprandial, reflected profound insulin deficiency in the setting of negative islet autoantibody testing, consistent with a diagnosis of fulminant type 1 diabetes. Ketoacidosis and hyperglycemia quickly improved following the introduction of insulin therapy, but not the β cell function. The patient received treatment with insulin pump therapy after being discharged, and the first follow-up revealed a well-controlled glucose profile.
Conclusions: New-onset FT1D can occur after SARS-CoV-2 infection. Our report raises awareness of this rare but serious situation, promoting early recognition and management of FT1D during the COVID-19 pandemic.
Keywords: case report; coronavirus disease 2019 (COVID- 19); fulminant type 1 diabetes; pregnancy; severe acute respiratory syndrome coronavirus 2.
. 2023 Apr 4;14:1168927.
doi: 10.3389/fendo.2023.1168927. eCollection 2023.
Case report: Fulminant type 1 diabetes following paucisymptomatic SARS-CoV-2 infection during late pregnancy
Lingling Zhou[SUP] 1 [/SUP], Huanjia Qu[SUP] 1 [/SUP], Qiuling Zhang[SUP] 1 [/SUP], Jinhua Hu[SUP] 1 [/SUP], Lan Shou[SUP] 1 [/SUP]
Affiliations
- PMID: 37082120
- PMCID: PMC10112664
- DOI: 10.3389/fendo.2023.1168927
Abstract
Background: Dysregulation of glucose metabolism has been linked to SARS-CoV-2 infection. In addition, the occurrence of new onset diabetes mellitus, including fulminant type 1 diabetes, has been reported after SARS-CoV-2 infection or vaccination.
Methods and results: A young Chinese woman in her last trimester of pregnancy presented with an abrupt progression of hyperglycemia and ketoacidosis, but with a near-normal glycohemoglobin level following paucisymptomatic SARS-CoV-2 infection. The low C peptide levels, both fasting and postprandial, reflected profound insulin deficiency in the setting of negative islet autoantibody testing, consistent with a diagnosis of fulminant type 1 diabetes. Ketoacidosis and hyperglycemia quickly improved following the introduction of insulin therapy, but not the β cell function. The patient received treatment with insulin pump therapy after being discharged, and the first follow-up revealed a well-controlled glucose profile.
Conclusions: New-onset FT1D can occur after SARS-CoV-2 infection. Our report raises awareness of this rare but serious situation, promoting early recognition and management of FT1D during the COVID-19 pandemic.
Keywords: case report; coronavirus disease 2019 (COVID- 19); fulminant type 1 diabetes; pregnancy; severe acute respiratory syndrome coronavirus 2.