tetano
Editor, Senior Moderator
Front Immunol
. 2021 Dec 22;12:788368.
doi: 10.3389/fimmu.2021.788368. eCollection 2021.
Anti-Interferon Autoantibodies in Adult-Onset Immunodeficiency Syndrome and Severe COVID-19 Infection
Long-Fang Chen[SUP] 1 [/SUP], Cheng-De Yang[SUP] 1 [/SUP], Xiao-Bing Cheng[SUP] 1 [/SUP]
Affiliations
Abstract
Adult-onset immunodeficiency syndrome due to anti-interferon (IFN)-γ autoantibodies has attracted much attention in recent years. It usually occurs in previously healthy people and usually presents as chronic, recurrent, and hard-to-control infections that can be effectively treated with aggressive antibiotic therapy. Adult-onset immunodeficiency syndrome is also referred to as AIDS-like syndrome. Anti-type I IFN (IFN-I) autoantibodies have been reported to play a significant role in the pathogenesis of coronavirus disease 2019 (COVID-19) and preexisting anti-IFN-I autoantibodies are associated with an increased risk of severe COVID-19. This review summarizes the effects of anti-IFN autoantibodies on the susceptibility and severity of various infectious diseases, including SARS-CoV-2 infection. In addition, we discuss the role of anti-IFN autoantibodies in the pathogenesis of autoimmune diseases that are characterized by recurrent infections.
Keywords: adult-onset immunodeficiency syndrome; autoantibodies against IFNs; autoimmune disease; coronavirus disease 2019 pneumonia; infectious disease.
. 2021 Dec 22;12:788368.
doi: 10.3389/fimmu.2021.788368. eCollection 2021.
Anti-Interferon Autoantibodies in Adult-Onset Immunodeficiency Syndrome and Severe COVID-19 Infection
Long-Fang Chen[SUP] 1 [/SUP], Cheng-De Yang[SUP] 1 [/SUP], Xiao-Bing Cheng[SUP] 1 [/SUP]
Affiliations
- PMID: 35003106
- PMCID: PMC8727472
- DOI: 10.3389/fimmu.2021.788368
Abstract
Adult-onset immunodeficiency syndrome due to anti-interferon (IFN)-γ autoantibodies has attracted much attention in recent years. It usually occurs in previously healthy people and usually presents as chronic, recurrent, and hard-to-control infections that can be effectively treated with aggressive antibiotic therapy. Adult-onset immunodeficiency syndrome is also referred to as AIDS-like syndrome. Anti-type I IFN (IFN-I) autoantibodies have been reported to play a significant role in the pathogenesis of coronavirus disease 2019 (COVID-19) and preexisting anti-IFN-I autoantibodies are associated with an increased risk of severe COVID-19. This review summarizes the effects of anti-IFN autoantibodies on the susceptibility and severity of various infectious diseases, including SARS-CoV-2 infection. In addition, we discuss the role of anti-IFN autoantibodies in the pathogenesis of autoimmune diseases that are characterized by recurrent infections.
Keywords: adult-onset immunodeficiency syndrome; autoantibodies against IFNs; autoimmune disease; coronavirus disease 2019 pneumonia; infectious disease.