tetano
Editor, Senior Moderator
Front Immunol
. 2023 Mar 24;14:1079277.
doi: 10.3389/fimmu.2023.1079277. eCollection 2023.
Clinical implications of gut microbiota and cytokine responses in coronavirus disease prognosis
Hye Seong[SUP] 1 2 3 [/SUP], Jun Hyoung Kim[SUP] 4 [/SUP], Young-Hee Han[SUP] 5 [/SUP], Ho Seong Seo[SUP] 6 [/SUP], Hak Jun Hyun[SUP] 1 3 [/SUP], Jin Gu Yoon[SUP] 1 3 [/SUP], Eliel Nham[SUP] 1 3 [/SUP], Ji Yun Noh[SUP] 1 2 3 [/SUP], Hee Jin Cheong[SUP] 1 2 3 [/SUP], Woo Joo Kim[SUP] 1 2 3 [/SUP], Sooyeon Lim[SUP] 2 3 [/SUP], Joon Young Song[SUP] 1 2 3 [/SUP]
Affiliations
Abstract
Objectives: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects gut luminal cells through the angiotensin-converting enzyme-2 receptor and disrupts the gut microbiome. We investigated whether the gut microbiome in the early stage of SARS-CoV-2 infection was associated with the prognosis of coronavirus disease (COVID-19).
Methods: Thirty COVID-19 patients and 16 healthy controls were prospectively enrolled. Blood and stool samples and clinical details were collected on days 0 (enrollment), 7, 14, and 28. Participants were categorized into four groups by their clinical course.
Results: Gut microbiota composition varied during the clinical course of COVID-19 and was closely associated with cytokine levels (p=0.003). A high abundance of the genus Dialister (linear discriminant analysis [LDA] effect size: 3.97856, p=0.004), species Peptoniphilus lacrimalis (LDA effect size: 4.00551, p=0.020), and Anaerococcus prevotii (LDA effect size: 4.00885, p=0.007) was associated with a good prognosis. Starch, sucrose, and galactose metabolism was highly activated in the gut microbiota of the poor prognosis group. Glucose-lowering diets, including whole grains, were positively correlated with a good prognosis.
Conclusion: Gut microbiota may mediate the prognosis of COVID-19 by regulating cytokine responses and controlling glucose metabolism, which is implicated in the host immune response to SARS-CoV-2.
Keywords: COVID-19; SARS-CoV-2; cytokine; functional markers; gut microbiota; host immune response; prognosis; taxonomic markers.
. 2023 Mar 24;14:1079277.
doi: 10.3389/fimmu.2023.1079277. eCollection 2023.
Clinical implications of gut microbiota and cytokine responses in coronavirus disease prognosis
Hye Seong[SUP] 1 2 3 [/SUP], Jun Hyoung Kim[SUP] 4 [/SUP], Young-Hee Han[SUP] 5 [/SUP], Ho Seong Seo[SUP] 6 [/SUP], Hak Jun Hyun[SUP] 1 3 [/SUP], Jin Gu Yoon[SUP] 1 3 [/SUP], Eliel Nham[SUP] 1 3 [/SUP], Ji Yun Noh[SUP] 1 2 3 [/SUP], Hee Jin Cheong[SUP] 1 2 3 [/SUP], Woo Joo Kim[SUP] 1 2 3 [/SUP], Sooyeon Lim[SUP] 2 3 [/SUP], Joon Young Song[SUP] 1 2 3 [/SUP]
Affiliations
- PMID: 37051240
- PMCID: PMC10083496
- DOI: 10.3389/fimmu.2023.1079277
Abstract
Objectives: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects gut luminal cells through the angiotensin-converting enzyme-2 receptor and disrupts the gut microbiome. We investigated whether the gut microbiome in the early stage of SARS-CoV-2 infection was associated with the prognosis of coronavirus disease (COVID-19).
Methods: Thirty COVID-19 patients and 16 healthy controls were prospectively enrolled. Blood and stool samples and clinical details were collected on days 0 (enrollment), 7, 14, and 28. Participants were categorized into four groups by their clinical course.
Results: Gut microbiota composition varied during the clinical course of COVID-19 and was closely associated with cytokine levels (p=0.003). A high abundance of the genus Dialister (linear discriminant analysis [LDA] effect size: 3.97856, p=0.004), species Peptoniphilus lacrimalis (LDA effect size: 4.00551, p=0.020), and Anaerococcus prevotii (LDA effect size: 4.00885, p=0.007) was associated with a good prognosis. Starch, sucrose, and galactose metabolism was highly activated in the gut microbiota of the poor prognosis group. Glucose-lowering diets, including whole grains, were positively correlated with a good prognosis.
Conclusion: Gut microbiota may mediate the prognosis of COVID-19 by regulating cytokine responses and controlling glucose metabolism, which is implicated in the host immune response to SARS-CoV-2.
Keywords: COVID-19; SARS-CoV-2; cytokine; functional markers; gut microbiota; host immune response; prognosis; taxonomic markers.