tetano
Editor, Senior Moderator
Front Immunol
. 2021 Jul 20;12:708184.
doi: 10.3389/fimmu.2021.708184. eCollection 2021.
Dynamic Characteristic Analysis of Antibodies in Patients With COVID-19: A 13-Month Study
Danrong Shi[SUP] 1 [/SUP], Tianhao Weng[SUP] 1 [/SUP], Jie Wu[SUP] 1 [/SUP], Chunyan Dai[SUP] 2 [/SUP], Rui Luo[SUP] 1 [/SUP], Keda Chen[SUP] 3 [/SUP], Miaojin Zhu[SUP] 1 [/SUP], Xiangyun Lu[SUP] 1 [/SUP], Linfang Cheng[SUP] 1 [/SUP], Qiuqiang Chen[SUP] 4 [/SUP], Fumin Liu[SUP] 1 [/SUP], Zhigang Wu[SUP] 1 [/SUP], Haibo Wu[SUP] 1 [/SUP], Changzhong Jin[SUP] 1 [/SUP], Miao Guo[SUP] 5 [/SUP], Zhe Chen[SUP] 2 [/SUP], Nanping Wu[SUP] 1 [/SUP], Hangping Yao[SUP] 1 [/SUP], Min Zheng[SUP] 1 [/SUP]
Affiliations
Abstract
There is a worldwide pandemic of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; yet our understanding remains limited on the characteristic of antibodies, especially for dynamic long-term tracking. Sequential serum samples were collected up to 416 days post onset of symptoms (POS) from 102 patients who were hospitalized with coronavirus disease 2019 (COVID-19). Immunoglobulin (Ig)G, IgM, and IgA levels targeting SARS-CoV-2 spike 1 receptor-binding domain (S1-RBD), spike 2 extracellular domain (S2-ECD), and nucleocapsid protein (N) were quantified as well as neutralizing activity. We were pleasantly surprised to find that the antibody remained detective and effective for more than a year POS. We also found the varied reactions of different antibodies as time passed: N-IgA rose most rapidly in the early stage of infection, while S2-IgG was present at a high level in the long time of observation. This study described the long traceable antibody response of the COVID-19 and offered hints about targets to screen for postinfectious immunity and for vaccination development of SARS-CoV-2.
Keywords: SARS-CoV-2; immunoreaction; neutralizing antibodies; nucleocapsid protein; receptor binding domain; spike glycoprotein.
. 2021 Jul 20;12:708184.
doi: 10.3389/fimmu.2021.708184. eCollection 2021.
Dynamic Characteristic Analysis of Antibodies in Patients With COVID-19: A 13-Month Study
Danrong Shi[SUP] 1 [/SUP], Tianhao Weng[SUP] 1 [/SUP], Jie Wu[SUP] 1 [/SUP], Chunyan Dai[SUP] 2 [/SUP], Rui Luo[SUP] 1 [/SUP], Keda Chen[SUP] 3 [/SUP], Miaojin Zhu[SUP] 1 [/SUP], Xiangyun Lu[SUP] 1 [/SUP], Linfang Cheng[SUP] 1 [/SUP], Qiuqiang Chen[SUP] 4 [/SUP], Fumin Liu[SUP] 1 [/SUP], Zhigang Wu[SUP] 1 [/SUP], Haibo Wu[SUP] 1 [/SUP], Changzhong Jin[SUP] 1 [/SUP], Miao Guo[SUP] 5 [/SUP], Zhe Chen[SUP] 2 [/SUP], Nanping Wu[SUP] 1 [/SUP], Hangping Yao[SUP] 1 [/SUP], Min Zheng[SUP] 1 [/SUP]
Affiliations
- PMID: 34354712
- PMCID: PMC8330131
- DOI: 10.3389/fimmu.2021.708184
Abstract
There is a worldwide pandemic of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; yet our understanding remains limited on the characteristic of antibodies, especially for dynamic long-term tracking. Sequential serum samples were collected up to 416 days post onset of symptoms (POS) from 102 patients who were hospitalized with coronavirus disease 2019 (COVID-19). Immunoglobulin (Ig)G, IgM, and IgA levels targeting SARS-CoV-2 spike 1 receptor-binding domain (S1-RBD), spike 2 extracellular domain (S2-ECD), and nucleocapsid protein (N) were quantified as well as neutralizing activity. We were pleasantly surprised to find that the antibody remained detective and effective for more than a year POS. We also found the varied reactions of different antibodies as time passed: N-IgA rose most rapidly in the early stage of infection, while S2-IgG was present at a high level in the long time of observation. This study described the long traceable antibody response of the COVID-19 and offered hints about targets to screen for postinfectious immunity and for vaccination development of SARS-CoV-2.
Keywords: SARS-CoV-2; immunoreaction; neutralizing antibodies; nucleocapsid protein; receptor binding domain; spike glycoprotein.