tetano
Editor, Senior Moderator
Front Immunol
. 2024 Nov 28:15:1430214.
doi: 10.3389/fimmu.2024.1430214. eCollection 2024. Long COVID symptoms 6 months after acute infection among people living with HIV and people not living with HIV
Qin Li[SUP] #[/SUP][SUP] 1 2 [/SUP], Yijie Ma[SUP] #[/SUP][SUP] 3 [/SUP], Peng He[SUP] #[/SUP][SUP] 4 [/SUP], Dongqiong Chen[SUP] 3 [/SUP], Tingrui Zhang[SUP] 3 [/SUP], Xiaoying Wang[SUP] 5 [/SUP], Ying Xu[SUP] 3 [/SUP], Peiming Li[SUP] 3 [/SUP], Weibo Wen[SUP] 2 3 [/SUP], Zefeng Wang[SUP] 6 [/SUP]
Affiliations
Background: Chronic viral infections, such as Human Immunodeficiency Virus (HIV), and their reactivation are considered potential contributing factors to Long-Corona Virus Disease (LC). However, research on the long-term sequelae of Long-COVID in individuals with HIV is limited.
Methods: We conducted a case-control study involving a total of 84 participants categorized into two groups: people living with HIV (PLWH) and people not living with HIV (PNLWH) within the six-month post-infection LC population. Differences in sequelae symptoms, cardiovascular biomarkers (VCAM-1, ICAM-1, and ACE2), Severe Acute Respiratory Syndrome Coronavirus 2 neutralization antibodies (SARS-CoV-2 nAb) and cytokines (IFN-γ, IL-6, and IL-17) were analyzed between the two groups.
Results: After 6 months of infection, PLWH exhibited significantly higher serum levels of ACE2, VCAM-1, and ICAM-1 (P < 0.01, respectively) compared to PNLWH with COVID-19. Additionally, sequelae symptoms were more pronounced in PNLWH, and there were no differences in serum levels of IFN-γ, TNF-α, IL-6, and IL-17 between the two groups (P > 0.05, respectively).
Conclusion: PLWH had lower symptoms of LC and reduced frequency of symptoms, increased cardiovascular risk factors, and no differences in levels of inflammation or SARS-CoV-2 nAb levels when compared to PNLWH.
Keywords: COVID-19; Long-COVID; cardiovascular biomarkers; human immunodeficiency virus; symptoms.
. 2024 Nov 28:15:1430214.
doi: 10.3389/fimmu.2024.1430214. eCollection 2024. Long COVID symptoms 6 months after acute infection among people living with HIV and people not living with HIV
Qin Li[SUP] #[/SUP][SUP] 1 2 [/SUP], Yijie Ma[SUP] #[/SUP][SUP] 3 [/SUP], Peng He[SUP] #[/SUP][SUP] 4 [/SUP], Dongqiong Chen[SUP] 3 [/SUP], Tingrui Zhang[SUP] 3 [/SUP], Xiaoying Wang[SUP] 5 [/SUP], Ying Xu[SUP] 3 [/SUP], Peiming Li[SUP] 3 [/SUP], Weibo Wen[SUP] 2 3 [/SUP], Zefeng Wang[SUP] 6 [/SUP]
Affiliations
- PMID: 39669584
- PMCID: PMC11634828
- DOI: 10.3389/fimmu.2024.1430214
Background: Chronic viral infections, such as Human Immunodeficiency Virus (HIV), and their reactivation are considered potential contributing factors to Long-Corona Virus Disease (LC). However, research on the long-term sequelae of Long-COVID in individuals with HIV is limited.
Methods: We conducted a case-control study involving a total of 84 participants categorized into two groups: people living with HIV (PLWH) and people not living with HIV (PNLWH) within the six-month post-infection LC population. Differences in sequelae symptoms, cardiovascular biomarkers (VCAM-1, ICAM-1, and ACE2), Severe Acute Respiratory Syndrome Coronavirus 2 neutralization antibodies (SARS-CoV-2 nAb) and cytokines (IFN-γ, IL-6, and IL-17) were analyzed between the two groups.
Results: After 6 months of infection, PLWH exhibited significantly higher serum levels of ACE2, VCAM-1, and ICAM-1 (P < 0.01, respectively) compared to PNLWH with COVID-19. Additionally, sequelae symptoms were more pronounced in PNLWH, and there were no differences in serum levels of IFN-γ, TNF-α, IL-6, and IL-17 between the two groups (P > 0.05, respectively).
Conclusion: PLWH had lower symptoms of LC and reduced frequency of symptoms, increased cardiovascular risk factors, and no differences in levels of inflammation or SARS-CoV-2 nAb levels when compared to PNLWH.
Keywords: COVID-19; Long-COVID; cardiovascular biomarkers; human immunodeficiency virus; symptoms.