tetano
Editor, Senior Moderator
Front Immunol
. 2021 Sep 30;12:758154.
doi: 10.3389/fimmu.2021.758154. eCollection 2021.
Normal T and B Cell Responses Against SARS-CoV-2 in a Family With a Non-Functional Vitamin D Receptor: A Case Report
Martin Kongsbak-Wismann[SUP] 1 [/SUP], Fatima A H Al-Jaberi[SUP] 1 [/SUP], Jonas Damgård Schmidt[SUP] 2 [/SUP], Mustafa Ghanizada[SUP] 2 [/SUP], Cecilie Bo Hansen[SUP] 3 [/SUP], Daniel Villalba Lopez[SUP] 1 [/SUP], Anders Woetmann[SUP] 1 [/SUP], Niels Ødum[SUP] 1 [/SUP], Charlotte Menné Bonefeld[SUP] 1 [/SUP], Anette Stryhn[SUP] 2 [/SUP], Peter Garred[SUP] 3 [/SUP], Søren Buus[SUP] 2 [/SUP], Carsten Geisler[SUP] 1 [/SUP]
Affiliations
Abstract
The coronavirus disease 2019 (COVID-19) pandemic has severely impacted daily life all over the world. Any measures to slow down the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to decrease disease severity are highly requested. Recent studies have reported inverse correlations between plasma levels of vitamin D and susceptibility to SARS-CoV-2 infection and COVID-19 severity. Therefore, it has been proposed to supplement the general population with vitamin D to reduce the impact of COVID-19. However, by studying the course of COVID-19 and the immune response against SARS-CoV-2 in a family with a mutated, non-functional vitamin D receptor, we here demonstrate that vitamin D signaling was dispensable for mounting an efficient adaptive immune response against SARS-CoV-2 in this family. Although these observations might not directly be transferred to the general population, they question a central role of vitamin D in the generation of adaptive immunity against SARS-CoV-2.
Keywords: COVID-19; HVDRR; SARS-CoV-2; adaptive immunity; vitamin D.
. 2021 Sep 30;12:758154.
doi: 10.3389/fimmu.2021.758154. eCollection 2021.
Normal T and B Cell Responses Against SARS-CoV-2 in a Family With a Non-Functional Vitamin D Receptor: A Case Report
Martin Kongsbak-Wismann[SUP] 1 [/SUP], Fatima A H Al-Jaberi[SUP] 1 [/SUP], Jonas Damgård Schmidt[SUP] 2 [/SUP], Mustafa Ghanizada[SUP] 2 [/SUP], Cecilie Bo Hansen[SUP] 3 [/SUP], Daniel Villalba Lopez[SUP] 1 [/SUP], Anders Woetmann[SUP] 1 [/SUP], Niels Ødum[SUP] 1 [/SUP], Charlotte Menné Bonefeld[SUP] 1 [/SUP], Anette Stryhn[SUP] 2 [/SUP], Peter Garred[SUP] 3 [/SUP], Søren Buus[SUP] 2 [/SUP], Carsten Geisler[SUP] 1 [/SUP]
Affiliations
- PMID: 34659264
- PMCID: PMC8515133
- DOI: 10.3389/fimmu.2021.758154
Abstract
The coronavirus disease 2019 (COVID-19) pandemic has severely impacted daily life all over the world. Any measures to slow down the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to decrease disease severity are highly requested. Recent studies have reported inverse correlations between plasma levels of vitamin D and susceptibility to SARS-CoV-2 infection and COVID-19 severity. Therefore, it has been proposed to supplement the general population with vitamin D to reduce the impact of COVID-19. However, by studying the course of COVID-19 and the immune response against SARS-CoV-2 in a family with a mutated, non-functional vitamin D receptor, we here demonstrate that vitamin D signaling was dispensable for mounting an efficient adaptive immune response against SARS-CoV-2 in this family. Although these observations might not directly be transferred to the general population, they question a central role of vitamin D in the generation of adaptive immunity against SARS-CoV-2.
Keywords: COVID-19; HVDRR; SARS-CoV-2; adaptive immunity; vitamin D.