tetano
Editor, Senior Moderator
Front Immunol
. 2025 Feb 4:16:1515768.
doi: 10.3389/fimmu.2025.1515768. eCollection 2025. Ocular neuroinflammatory response secondary to SARS-CoV-2 infection-a review
Yun Zhao[SUP] 1 [/SUP], Ying Tang[SUP] 1 [/SUP], Qi Yao Wang[SUP] 1 [/SUP], Jia Li[SUP] 1 [/SUP]
Affiliations
With the consistent occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the prevalence of various ocular complications has increased over time. SARS-CoV-2 infection has been shown to have neurotropism and therefore to lead to not only peripheral inflammatory responses but also neuroinflammation. Because the receptor for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2), can be found in many intraocular tissues, coronavirus disease 2019 (COVID-19) may also contribute to persistent intraocular neuroinflammation, microcirculation dysfunction and ocular symptoms. Increased awareness of neuroinflammation and future research on interventional strategies for SARS-CoV-2 infection are important for improving long-term outcomes, reducing disease burden, and improving quality of life. Therefore, the aim of this review is to focus on SARS-CoV-2 infection and intraocular neuroinflammation and to discuss current evidence and future perspectives, especially possible connections between conditions and potential treatment strategies.
Keywords: COVID-19; SARS-CoV-2; neuroinflammation; ocular complications; ocular manifestations.
. 2025 Feb 4:16:1515768.
doi: 10.3389/fimmu.2025.1515768. eCollection 2025. Ocular neuroinflammatory response secondary to SARS-CoV-2 infection-a review
Yun Zhao[SUP] 1 [/SUP], Ying Tang[SUP] 1 [/SUP], Qi Yao Wang[SUP] 1 [/SUP], Jia Li[SUP] 1 [/SUP]
Affiliations
- PMID: 39967658
- PMCID: PMC11832381
- DOI: 10.3389/fimmu.2025.1515768
With the consistent occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the prevalence of various ocular complications has increased over time. SARS-CoV-2 infection has been shown to have neurotropism and therefore to lead to not only peripheral inflammatory responses but also neuroinflammation. Because the receptor for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2), can be found in many intraocular tissues, coronavirus disease 2019 (COVID-19) may also contribute to persistent intraocular neuroinflammation, microcirculation dysfunction and ocular symptoms. Increased awareness of neuroinflammation and future research on interventional strategies for SARS-CoV-2 infection are important for improving long-term outcomes, reducing disease burden, and improving quality of life. Therefore, the aim of this review is to focus on SARS-CoV-2 infection and intraocular neuroinflammation and to discuss current evidence and future perspectives, especially possible connections between conditions and potential treatment strategies.
Keywords: COVID-19; SARS-CoV-2; neuroinflammation; ocular complications; ocular manifestations.