tetano
Editor, Senior Moderator
Front Immunol
. 2024 Sep 11:15:1392898.
doi: 10.3389/fimmu.2024.1392898. eCollection 2024. Strategies for developing self-assembled nanoparticle vaccines against SARS-CoV-2 infection
Kaiwen Yang[SUP] 1 2 [/SUP], Youqin Zeng[SUP] 1 2 [/SUP], Xinyu Wu[SUP] 1 2 [/SUP], Jia Li[SUP] 1 2 [/SUP], Jinlin Guo[SUP] 1 2 [/SUP]
Affiliations
In the recent history of the SARS-CoV-2 outbreak, vaccines have been a crucial public health tool, playing a significant role in effectively preventing infections. However, improving the efficacy while minimizing side effects remains a major challenge. In recent years, there has been growing interest in nanoparticle-based delivery systems aimed at improving antigen delivery efficiency and immunogenicity. Among these, self-assembled nanoparticles with varying sizes, shapes, and surface properties have garnered considerable attention. This paper reviews the latest advancements in the design and development of SARS-CoV-2 vaccines utilizing self-assembled materials, highlighting their advantages in delivering viral immunogens. In addition, we briefly discuss strategies for designing a broad-spectrum universal vaccine, which provides insights and ideas for dealing with possible future infectious sarbecoviruses.
Keywords: SARS-CoV-2; VLP; ferritin; self-assembled nanoparticle; vaccine.
. 2024 Sep 11:15:1392898.
doi: 10.3389/fimmu.2024.1392898. eCollection 2024. Strategies for developing self-assembled nanoparticle vaccines against SARS-CoV-2 infection
Kaiwen Yang[SUP] 1 2 [/SUP], Youqin Zeng[SUP] 1 2 [/SUP], Xinyu Wu[SUP] 1 2 [/SUP], Jia Li[SUP] 1 2 [/SUP], Jinlin Guo[SUP] 1 2 [/SUP]
Affiliations
- PMID: 39351240
- PMCID: PMC11440195
- DOI: 10.3389/fimmu.2024.1392898
In the recent history of the SARS-CoV-2 outbreak, vaccines have been a crucial public health tool, playing a significant role in effectively preventing infections. However, improving the efficacy while minimizing side effects remains a major challenge. In recent years, there has been growing interest in nanoparticle-based delivery systems aimed at improving antigen delivery efficiency and immunogenicity. Among these, self-assembled nanoparticles with varying sizes, shapes, and surface properties have garnered considerable attention. This paper reviews the latest advancements in the design and development of SARS-CoV-2 vaccines utilizing self-assembled materials, highlighting their advantages in delivering viral immunogens. In addition, we briefly discuss strategies for designing a broad-spectrum universal vaccine, which provides insights and ideas for dealing with possible future infectious sarbecoviruses.
Keywords: SARS-CoV-2; VLP; ferritin; self-assembled nanoparticle; vaccine.