tetano
Editor, Senior Moderator
Front Immunol
. 2022 Jul 27;13:951107.
doi: 10.3389/fimmu.2022.951107. eCollection 2022.
The role of interleukin-22 in lung health and its therapeutic potential for COVID-19
Si Fang[SUP] 1 [/SUP], Dianwen Ju[SUP] 2 [/SUP], Yong Lin[SUP] 1 [/SUP], Wei Chen[SUP] 1 3 [/SUP]
Affiliations
Abstract
Although numerous clinical trials have been implemented, an absolutely effective treatment against coronavirus disease 2019 (COVID-19) is still elusive. Interleukin-22 (IL-22) has attracted great interest over recent years, making it one of the best-studied cytokines of the interleukin-10 (IL-10) family. Unlike most interleukins, the major impact of IL-22 is exclusively on fibroblasts and epithelial cells due to the restricted expression of receptor. Numerous studies have suggested that IL-22 plays a crucial role in anti-viral infections through significantly ameliorating the immune cell-mediated inflammatory responses, and reducing tissue injury as well as further promoting epithelial repair and regeneration. Herein, we pay special attention to the role of IL-22 in the lungs. We summarize the latest progress in our understanding of IL-22 in lung health and disease and further discuss maneuvering this cytokine as potential immunotherapeutic strategy for the effective manage of COVID-19.
Keywords: COVID-19; SARS-CoV-2 infection; immunotherapeutic strategy; interleukin-22; lung.
. 2022 Jul 27;13:951107.
doi: 10.3389/fimmu.2022.951107. eCollection 2022.
The role of interleukin-22 in lung health and its therapeutic potential for COVID-19
Si Fang[SUP] 1 [/SUP], Dianwen Ju[SUP] 2 [/SUP], Yong Lin[SUP] 1 [/SUP], Wei Chen[SUP] 1 3 [/SUP]
Affiliations
- PMID: 35967401
- PMCID: PMC9364265
- DOI: 10.3389/fimmu.2022.951107
Abstract
Although numerous clinical trials have been implemented, an absolutely effective treatment against coronavirus disease 2019 (COVID-19) is still elusive. Interleukin-22 (IL-22) has attracted great interest over recent years, making it one of the best-studied cytokines of the interleukin-10 (IL-10) family. Unlike most interleukins, the major impact of IL-22 is exclusively on fibroblasts and epithelial cells due to the restricted expression of receptor. Numerous studies have suggested that IL-22 plays a crucial role in anti-viral infections through significantly ameliorating the immune cell-mediated inflammatory responses, and reducing tissue injury as well as further promoting epithelial repair and regeneration. Herein, we pay special attention to the role of IL-22 in the lungs. We summarize the latest progress in our understanding of IL-22 in lung health and disease and further discuss maneuvering this cytokine as potential immunotherapeutic strategy for the effective manage of COVID-19.
Keywords: COVID-19; SARS-CoV-2 infection; immunotherapeutic strategy; interleukin-22; lung.