tetano
Editor, Senior Moderator
Front Med (Lausanne)
. 2021 Nov 22;8:760823.
doi: 10.3389/fmed.2021.760823. eCollection 2021.
Case Report: Infantile Bullous Pemphigoid: Triggering by COVID-19 Is Speculative
Anna Rosińska-Więckowicz[SUP] 1 [/SUP], Magdalena Jałowska[SUP] 1 [/SUP], Monika Bowszyc-Dmochowska[SUP] 2 [/SUP], Marian Dmochowski[SUP] 1 [/SUP]
Affiliations
Abstract
Bullous pemphigoid (BP) is a cutaneous disease triggered by numerous stimuli, where genetic milieu-influenced autoimmunity to hemidesmosomal proteins, namely, BP180 and/or BP230 initiate an inflammation leading to dermal-epidermal junction (DEJ) enzymatic pathological remodelling. Here, to the best of our knowledge, we present the first case of an infantile BP apparently triggered by COVID-19. BP should be included in differential diagnosis of infantile rashes showing blisters or vesicles or both as well as their prodromal and evolutionary lesions. Possible triggers, such as coronavirus disease 2019 (COVID-19), of BP in infancy should be identified and properly dealt with.
Keywords: COVID-19; RT-PCR; autoimmune blistering; bullous pemphigoid; infants.
. 2021 Nov 22;8:760823.
doi: 10.3389/fmed.2021.760823. eCollection 2021.
Case Report: Infantile Bullous Pemphigoid: Triggering by COVID-19 Is Speculative
Anna Rosińska-Więckowicz[SUP] 1 [/SUP], Magdalena Jałowska[SUP] 1 [/SUP], Monika Bowszyc-Dmochowska[SUP] 2 [/SUP], Marian Dmochowski[SUP] 1 [/SUP]
Affiliations
- PMID: 34881262
- PMCID: PMC8647993
- DOI: 10.3389/fmed.2021.760823
Abstract
Bullous pemphigoid (BP) is a cutaneous disease triggered by numerous stimuli, where genetic milieu-influenced autoimmunity to hemidesmosomal proteins, namely, BP180 and/or BP230 initiate an inflammation leading to dermal-epidermal junction (DEJ) enzymatic pathological remodelling. Here, to the best of our knowledge, we present the first case of an infantile BP apparently triggered by COVID-19. BP should be included in differential diagnosis of infantile rashes showing blisters or vesicles or both as well as their prodromal and evolutionary lesions. Possible triggers, such as coronavirus disease 2019 (COVID-19), of BP in infancy should be identified and properly dealt with.
Keywords: COVID-19; RT-PCR; autoimmune blistering; bullous pemphigoid; infants.