tetano
Editor, Senior Moderator
Front Med (Lausanne)
. 2022 Feb 14;9:809033.
doi: 10.3389/fmed.2022.809033. eCollection 2022.
Persistent Endothelial Dysfunction in Coronavirus Disease-2019 Survivors Late After Recovery
Yi-Ping Gao[SUP] 1 [/SUP], Wei Zhou[SUP] 1 [/SUP], Pei-Na Huang[SUP] 1 [/SUP], Hong-Yun Liu[SUP] 1 [/SUP], Xiao-Jun Bi[SUP] 1 [/SUP], Ying Zhu[SUP] 1 [/SUP], Jie Sun[SUP] 1 [/SUP], Qiao-Ying Tang[SUP] 1 [/SUP], Li Li[SUP] 1 [/SUP], Jun Zhang[SUP] 1 [/SUP], Wei-Hong Zhu[SUP] 1 [/SUP], Xue-Qing Cheng[SUP] 1 [/SUP], Ya-Ni Liu[SUP] 1 [/SUP], You-Bin Deng[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Coronavirus disease 2019 (COVID-19) can result in an endothelial dysfunction in acute phase. However, information on the late vascular consequences of COVID-19 is limited.
Methods: Brachial artery flow-mediated dilation (FMD) examination were performed, and inflammatory biomarkers were assessed in 86 survivors of COVID-19 for 327 days (IQR 318-337 days) after recovery. Comparisons were made with 28 age-matched and sex-matched healthy controls and 30 risk factor-matched patients.
Results: Brachial artery FMD was significantly lower in the survivors of COVID-19 than in the healthy controls and risk factor-matched controls [median (IQR) 7.7 (5.1-10.7)% for healthy controls, 6.9 (5.5-9.4)% for risk factor-matched controls, and 3.5(2.2-4.6)% for COVID-19, respectively, p < 0.001]. The FMD was lower in 25 patients with elevated tumor necrosis factor (TNF)-α [2.7(1.2-3.9)] than in 61 patients without elevated TNF-α [3.8(2.6-5.3), p = 0.012]. Furthermore, FMD was inversely correlated with serum concentration of TNF-α (r = -0.237, p = 0.007).
Conclusion: Survivors of COVID-19 have a reduced brachial artery FMD, which is inversely correlated with increased serum concentration of TNF-α. Prospective studies on the association of endothelial dysfunction with long-term cardiovascular outcomes, especially the early onset of atherosclerosis, are warranted in survivors of COVID-19.
Keywords: COVID-19; TNF-α; endothelial function; flow-mediated dilation; inflammation.
. 2022 Feb 14;9:809033.
doi: 10.3389/fmed.2022.809033. eCollection 2022.
Persistent Endothelial Dysfunction in Coronavirus Disease-2019 Survivors Late After Recovery
Yi-Ping Gao[SUP] 1 [/SUP], Wei Zhou[SUP] 1 [/SUP], Pei-Na Huang[SUP] 1 [/SUP], Hong-Yun Liu[SUP] 1 [/SUP], Xiao-Jun Bi[SUP] 1 [/SUP], Ying Zhu[SUP] 1 [/SUP], Jie Sun[SUP] 1 [/SUP], Qiao-Ying Tang[SUP] 1 [/SUP], Li Li[SUP] 1 [/SUP], Jun Zhang[SUP] 1 [/SUP], Wei-Hong Zhu[SUP] 1 [/SUP], Xue-Qing Cheng[SUP] 1 [/SUP], Ya-Ni Liu[SUP] 1 [/SUP], You-Bin Deng[SUP] 1 [/SUP]
Affiliations
- PMID: 35237624
- PMCID: PMC8882598
- DOI: 10.3389/fmed.2022.809033
Abstract
Background: Coronavirus disease 2019 (COVID-19) can result in an endothelial dysfunction in acute phase. However, information on the late vascular consequences of COVID-19 is limited.
Methods: Brachial artery flow-mediated dilation (FMD) examination were performed, and inflammatory biomarkers were assessed in 86 survivors of COVID-19 for 327 days (IQR 318-337 days) after recovery. Comparisons were made with 28 age-matched and sex-matched healthy controls and 30 risk factor-matched patients.
Results: Brachial artery FMD was significantly lower in the survivors of COVID-19 than in the healthy controls and risk factor-matched controls [median (IQR) 7.7 (5.1-10.7)% for healthy controls, 6.9 (5.5-9.4)% for risk factor-matched controls, and 3.5(2.2-4.6)% for COVID-19, respectively, p < 0.001]. The FMD was lower in 25 patients with elevated tumor necrosis factor (TNF)-α [2.7(1.2-3.9)] than in 61 patients without elevated TNF-α [3.8(2.6-5.3), p = 0.012]. Furthermore, FMD was inversely correlated with serum concentration of TNF-α (r = -0.237, p = 0.007).
Conclusion: Survivors of COVID-19 have a reduced brachial artery FMD, which is inversely correlated with increased serum concentration of TNF-α. Prospective studies on the association of endothelial dysfunction with long-term cardiovascular outcomes, especially the early onset of atherosclerosis, are warranted in survivors of COVID-19.
Keywords: COVID-19; TNF-α; endothelial function; flow-mediated dilation; inflammation.