tetano
Editor, Senior Moderator
Front Med (Lausanne)
. 2022 Jan 13;8:686878.
doi: 10.3389/fmed.2021.686878. eCollection 2021.
Pulmonary Sequelae in Patients After Recovery From Coronavirus Disease 2019: A Follow-Up Study With Chest CT
Xuejiao Liao[SUP] 1 2 [/SUP], Dapeng Li[SUP] 2 3 [/SUP], Zhi Liu[SUP] 4 [/SUP], Zhenghua Ma[SUP] 1 [/SUP], Lina Zhang[SUP] 1 [/SUP], Jingke Dong[SUP] 1 [/SUP], Yirong Shi[SUP] 1 [/SUP], Xiaowen Gu[SUP] 1 [/SUP], Guangping Zheng[SUP] 5 [/SUP], Ling Huang[SUP] 4 [/SUP], Lijun Yuan[SUP] 3 [/SUP], Jing Cao[SUP] 3 [/SUP], Dan Shu[SUP] 2 [/SUP], Xiangyi Yang[SUP] 2 [/SUP], Qing He[SUP] 3 [/SUP], Guobao Li[SUP] 4 [/SUP], Zheng Zhang[SUP] 2 3 [/SUP], Lei Liu[SUP] 3 [/SUP]
Affiliations
Abstract
Objective: The pulmonary sequelae of coronavirus disease 2019 (COVID-19) have not been comprehensively evaluated. We performed a follow-up study analyzing chest computed tomography (CT) findings of COVID-19 patients at 3 and 6 months after hospital discharge. Methods: Between February 2020 and May 2020, a total of 273 patients with COVID-19 at the Shenzhen Third People's Hospital were recruited and followed for 6 months after discharge. Chest CT scanning was performed with the patient in the supine position at end-inspiration. A total of 957 chest CT scans was obtained at different timepoints. A semi-quantitative score was used to assess the degree of lung involvement. Results: Most chest CT scans showed bilateral lung involvement with peripheral location at 3 and 6 months follow-up. The most common CT findings were ground-glass opacity and parenchymal band, which were found in 136 (55.3%) and 94 (38.2%) of the 246 patients at 3 months follow-up, and 82 (48.2%) and 76 (44.7%) of 170 patients at 6 months follow-up, respectively. The number of lobes involved and the total CT severity score declined over time. The total CT score gradually increased with the increasement of disease severity at both 3 months follow-up (trend test P < 0.001) and 6 months follow-up (trend test P < 0.001). Patients with different disease severity represented diverse CT patterns over time. Conclusions: The most common CT findings were ground-glass opacity and parenchymal bands at the 3 and 6 months follow-up. Patients with different disease severity represent diverse CT manifestations, indicating the necessary for long-term follow-up monitoring of patients with severe and critical conditions.
Keywords: computed tomography; coronavirus disease 2019 (COVID-19); follow-up; pulmonary sequelae; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
. 2022 Jan 13;8:686878.
doi: 10.3389/fmed.2021.686878. eCollection 2021.
Pulmonary Sequelae in Patients After Recovery From Coronavirus Disease 2019: A Follow-Up Study With Chest CT
Xuejiao Liao[SUP] 1 2 [/SUP], Dapeng Li[SUP] 2 3 [/SUP], Zhi Liu[SUP] 4 [/SUP], Zhenghua Ma[SUP] 1 [/SUP], Lina Zhang[SUP] 1 [/SUP], Jingke Dong[SUP] 1 [/SUP], Yirong Shi[SUP] 1 [/SUP], Xiaowen Gu[SUP] 1 [/SUP], Guangping Zheng[SUP] 5 [/SUP], Ling Huang[SUP] 4 [/SUP], Lijun Yuan[SUP] 3 [/SUP], Jing Cao[SUP] 3 [/SUP], Dan Shu[SUP] 2 [/SUP], Xiangyi Yang[SUP] 2 [/SUP], Qing He[SUP] 3 [/SUP], Guobao Li[SUP] 4 [/SUP], Zheng Zhang[SUP] 2 3 [/SUP], Lei Liu[SUP] 3 [/SUP]
Affiliations
- PMID: 35096849
- PMCID: PMC8794727
- DOI: 10.3389/fmed.2021.686878
Abstract
Objective: The pulmonary sequelae of coronavirus disease 2019 (COVID-19) have not been comprehensively evaluated. We performed a follow-up study analyzing chest computed tomography (CT) findings of COVID-19 patients at 3 and 6 months after hospital discharge. Methods: Between February 2020 and May 2020, a total of 273 patients with COVID-19 at the Shenzhen Third People's Hospital were recruited and followed for 6 months after discharge. Chest CT scanning was performed with the patient in the supine position at end-inspiration. A total of 957 chest CT scans was obtained at different timepoints. A semi-quantitative score was used to assess the degree of lung involvement. Results: Most chest CT scans showed bilateral lung involvement with peripheral location at 3 and 6 months follow-up. The most common CT findings were ground-glass opacity and parenchymal band, which were found in 136 (55.3%) and 94 (38.2%) of the 246 patients at 3 months follow-up, and 82 (48.2%) and 76 (44.7%) of 170 patients at 6 months follow-up, respectively. The number of lobes involved and the total CT severity score declined over time. The total CT score gradually increased with the increasement of disease severity at both 3 months follow-up (trend test P < 0.001) and 6 months follow-up (trend test P < 0.001). Patients with different disease severity represented diverse CT patterns over time. Conclusions: The most common CT findings were ground-glass opacity and parenchymal bands at the 3 and 6 months follow-up. Patients with different disease severity represent diverse CT manifestations, indicating the necessary for long-term follow-up monitoring of patients with severe and critical conditions.
Keywords: computed tomography; coronavirus disease 2019 (COVID-19); follow-up; pulmonary sequelae; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).