tetano
Editor, Senior Moderator
Front Med (Lausanne)
. 2022 Jan 31;8:836826.
doi: 10.3389/fmed.2021.836826. eCollection 2021.
Viral Load in COVID-19 Patients: Implications for Prognosis and Vaccine Efficacy in the Context of Emerging SARS-CoV-2 Variants
Severino Jefferson Ribeiro da Silva[SUP] 1 2 [/SUP], Suelen Cristina de Lima[SUP] 1 [/SUP], Ronaldo Celerino da Silva[SUP] 1 [/SUP], Alain Kohl[SUP] 3 [/SUP], Lindomar Pena[SUP] 1 [/SUP]
Affiliations
Abstract
The worldwide spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused an unprecedented public health crisis in the 21st century. As the pandemic evolves, the emergence of SARS-CoV-2 has been characterized by the emergence of new variants of concern (VOCs), which resulted in a catastrophic impact on SARS-CoV-2 infection. In light of this, research groups around the world are unraveling key aspects of the associated illness, coronavirus disease 2019 (COVID-19). A cumulative body of data has indicated that the SARS-CoV-2 viral load may be a determinant of the COVID-19 severity. Here we summarize the main characteristics of the emerging variants of SARS-CoV-2, discussing their impact on viral transmissibility, viral load, disease severity, vaccine breakthrough, and lethality among COVID-19 patients. We also provide a rundown of the rapidly expanding scientific evidence from clinical studies and animal models that indicate how viral load could be linked to COVID-19 prognosis and vaccine efficacy among vaccinated individuals, highlighting the differences compared to unvaccinated individuals.
Keywords: SARS-CoV-2; disease severity; emerging variants; lethality; prognosis; transmissibility; vaccines; viral load.
. 2022 Jan 31;8:836826.
doi: 10.3389/fmed.2021.836826. eCollection 2021.
Viral Load in COVID-19 Patients: Implications for Prognosis and Vaccine Efficacy in the Context of Emerging SARS-CoV-2 Variants
Severino Jefferson Ribeiro da Silva[SUP] 1 2 [/SUP], Suelen Cristina de Lima[SUP] 1 [/SUP], Ronaldo Celerino da Silva[SUP] 1 [/SUP], Alain Kohl[SUP] 3 [/SUP], Lindomar Pena[SUP] 1 [/SUP]
Affiliations
- PMID: 35174189
- PMCID: PMC8841511
- DOI: 10.3389/fmed.2021.836826
Abstract
The worldwide spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused an unprecedented public health crisis in the 21st century. As the pandemic evolves, the emergence of SARS-CoV-2 has been characterized by the emergence of new variants of concern (VOCs), which resulted in a catastrophic impact on SARS-CoV-2 infection. In light of this, research groups around the world are unraveling key aspects of the associated illness, coronavirus disease 2019 (COVID-19). A cumulative body of data has indicated that the SARS-CoV-2 viral load may be a determinant of the COVID-19 severity. Here we summarize the main characteristics of the emerging variants of SARS-CoV-2, discussing their impact on viral transmissibility, viral load, disease severity, vaccine breakthrough, and lethality among COVID-19 patients. We also provide a rundown of the rapidly expanding scientific evidence from clinical studies and animal models that indicate how viral load could be linked to COVID-19 prognosis and vaccine efficacy among vaccinated individuals, highlighting the differences compared to unvaccinated individuals.
Keywords: SARS-CoV-2; disease severity; emerging variants; lethality; prognosis; transmissibility; vaccines; viral load.