tetano
Editor, Senior Moderator
Front Microbiol
. 2021 Aug 2;12:724654.
doi: 10.3389/fmicb.2021.724654. eCollection 2021.
Chronic SARS-CoV-2, a Cause of Post-acute COVID-19 Sequelae (Long-COVID)?
Jake S O'Donnell[SUP] 1 2 [/SUP], Keith J Chappell[SUP] 1 2 3 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause coronavirus disease 2019 (COVID-19). Most individuals recover from SARS-CoV-2 infection, however, many continue to experience a cluster of persistent symptoms for months following resolution of acute disease; a syndrome that has been named Long-COVID. While the biological cause, or causes, of Long-COVID have not yet been confirmed, the main proposals have centred around either virus-induced autoimmunity or virus-induced tissue dysfunction. However, an alternative suggestion that a latent chronic infection could be responsible for the symptoms of Long-COVID has received minimal attention despite recent findings that SARS-CoV-2 genetic material and infections are detected in some individuals months following resolution of respiratory disease. Here we discuss literature supporting the possibility that Long-COVID occurs as a result of chronic SARS-CoV-2 infections.
Keywords: COVID-19; Long-COVID-syndrome; chronic; gut flora; immunology.
. 2021 Aug 2;12:724654.
doi: 10.3389/fmicb.2021.724654. eCollection 2021.
Chronic SARS-CoV-2, a Cause of Post-acute COVID-19 Sequelae (Long-COVID)?
Jake S O'Donnell[SUP] 1 2 [/SUP], Keith J Chappell[SUP] 1 2 3 [/SUP]
Affiliations
- PMID: 34408742
- PMCID: PMC8365243
- DOI: 10.3389/fmicb.2021.724654
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause coronavirus disease 2019 (COVID-19). Most individuals recover from SARS-CoV-2 infection, however, many continue to experience a cluster of persistent symptoms for months following resolution of acute disease; a syndrome that has been named Long-COVID. While the biological cause, or causes, of Long-COVID have not yet been confirmed, the main proposals have centred around either virus-induced autoimmunity or virus-induced tissue dysfunction. However, an alternative suggestion that a latent chronic infection could be responsible for the symptoms of Long-COVID has received minimal attention despite recent findings that SARS-CoV-2 genetic material and infections are detected in some individuals months following resolution of respiratory disease. Here we discuss literature supporting the possibility that Long-COVID occurs as a result of chronic SARS-CoV-2 infections.
Keywords: COVID-19; Long-COVID-syndrome; chronic; gut flora; immunology.