tetano
Editor, Senior Moderator
Front Microbiol
. 2022 Oct 21;13:1002670.
doi: 10.3389/fmicb.2022.1002670. eCollection 2022.
Etiologic characteristics of avian influenza H11 viruses isolated from the live poultry market in southeast coastal region in China
Lina Jiang[SUP] 1 [/SUP], Jiaming Li[SUP] 2 [/SUP], Huan Cui[SUP] 3 [/SUP], Cheng Zhang[SUP] 3 [/SUP], Yifei Jin[SUP] 2 [/SUP], Yingying Fu[SUP] 2 [/SUP], Ningning Ma[SUP] 4 [/SUP], Fei Tang[SUP] 1 [/SUP], Yidun Zhang[SUP] 1 [/SUP], Jing Zheng[SUP] 1 [/SUP], Li Li[SUP] 1 [/SUP], Bing Lu[SUP] 2 [/SUP], Zehui Chen[SUP] 1 [/SUP], Zhendong Guo[SUP] 3 [/SUP], Zhongyi Wang[SUP] 2 [/SUP]
Affiliations
Abstract
Since it was first identified in 1956, the H11 subvariant influenza virus has been reported worldwide. However, due to the low pathogenicity of the H11 subvariant and the absence of its widespread transmission among humans, there are only a few reports on the etiology of the H11 subvariant influenza virus. Therefore, in the present study, we isolated a strain of the H11N3 avian influenza virus (AIV) from poultry feces from the live poultry market in the southeast coastal region of China. Considering that the H11 subvariant is known to cause infections in humans and to enrich the knowledge of the H11 subvariant of the avian influenza virus, the genetics, pathogenicity, and transmissibility of the isolate were studied. The phylogenetic analysis indicated that the H11N3 isolate was of Eurasian origin and carried genes closely related to duck H7N2 and H4N6. The receptor binding analysis revealed that the H11N3 isolate only acquired a binding affinity for avian-derived receptors. In the respiratory system of mice, the isolate could directly cause infection without adaptation. In addition, the results from transmission experiments and antibody detection in guinea pigs demonstrated that H11N3 influenza viruses can efficiently transmit through the respiratory tract in mammalian models. Direct infection of the H11N3 influenza virus without adaptation in the mouse models and aerosol transmission between guinea pig models confirms its pandemic potential in mammals, underscoring the importance of monitoring rare influenza virus subtypes in future studies.
Keywords: H11N3 influenza virus; live poultry market; mammals; rare subtypes; transmission.
. 2022 Oct 21;13:1002670.
doi: 10.3389/fmicb.2022.1002670. eCollection 2022.
Etiologic characteristics of avian influenza H11 viruses isolated from the live poultry market in southeast coastal region in China
Lina Jiang[SUP] 1 [/SUP], Jiaming Li[SUP] 2 [/SUP], Huan Cui[SUP] 3 [/SUP], Cheng Zhang[SUP] 3 [/SUP], Yifei Jin[SUP] 2 [/SUP], Yingying Fu[SUP] 2 [/SUP], Ningning Ma[SUP] 4 [/SUP], Fei Tang[SUP] 1 [/SUP], Yidun Zhang[SUP] 1 [/SUP], Jing Zheng[SUP] 1 [/SUP], Li Li[SUP] 1 [/SUP], Bing Lu[SUP] 2 [/SUP], Zehui Chen[SUP] 1 [/SUP], Zhendong Guo[SUP] 3 [/SUP], Zhongyi Wang[SUP] 2 [/SUP]
Affiliations
- PMID: 36338057
- PMCID: PMC9634483
- DOI: 10.3389/fmicb.2022.1002670
Abstract
Since it was first identified in 1956, the H11 subvariant influenza virus has been reported worldwide. However, due to the low pathogenicity of the H11 subvariant and the absence of its widespread transmission among humans, there are only a few reports on the etiology of the H11 subvariant influenza virus. Therefore, in the present study, we isolated a strain of the H11N3 avian influenza virus (AIV) from poultry feces from the live poultry market in the southeast coastal region of China. Considering that the H11 subvariant is known to cause infections in humans and to enrich the knowledge of the H11 subvariant of the avian influenza virus, the genetics, pathogenicity, and transmissibility of the isolate were studied. The phylogenetic analysis indicated that the H11N3 isolate was of Eurasian origin and carried genes closely related to duck H7N2 and H4N6. The receptor binding analysis revealed that the H11N3 isolate only acquired a binding affinity for avian-derived receptors. In the respiratory system of mice, the isolate could directly cause infection without adaptation. In addition, the results from transmission experiments and antibody detection in guinea pigs demonstrated that H11N3 influenza viruses can efficiently transmit through the respiratory tract in mammalian models. Direct infection of the H11N3 influenza virus without adaptation in the mouse models and aerosol transmission between guinea pig models confirms its pandemic potential in mammals, underscoring the importance of monitoring rare influenza virus subtypes in future studies.
Keywords: H11N3 influenza virus; live poultry market; mammals; rare subtypes; transmission.