tetano
Editor, Senior Moderator
Front Microbiol
. 2022 Feb 22;13:828806.
doi: 10.3389/fmicb.2022.828806. eCollection 2022.
Protection Duration of COVID-19 Vaccines: Waning Effectiveness and Future Perspective
Chunlan Zhuang[SUP] 1 [/SUP], Xiaohui Liu[SUP] 1 [/SUP], Qi Chen[SUP] 1 [/SUP], Yuxin Sun[SUP] 2 [/SUP], Yingying Su[SUP] 1 [/SUP], Shoujie Huang[SUP] 1 [/SUP], Ting Wu[SUP] 1 [/SUP], Ningshao Xia[SUP] 1 3 [/SUP]
Affiliations
Abstract
The coronavirus disease 2019 (COVID-19) vaccines have very successfully decreased the disease risk as we know; some key information remains unknown due to the short development history and the lack of long-term follow-up studies in vaccinated populations. One of the unanswered issues is the protection duration conferred after COVID-19 vaccination, which appears to play a pivotal role in the future impact of pathogens and is critical to inform the public health response and policy decisions. Here, we review current information on the long-term effectiveness of different COVID-19 vaccines, persistence of immunogenicity, and gaps in knowledge. Meanwhile, we also discuss the influencing factors and future study prospects on this topic.
Keywords: COVID-19; SARS-CoV-2 variant; protection duration; vaccines; waning effectiveness.
. 2022 Feb 22;13:828806.
doi: 10.3389/fmicb.2022.828806. eCollection 2022.
Protection Duration of COVID-19 Vaccines: Waning Effectiveness and Future Perspective
Chunlan Zhuang[SUP] 1 [/SUP], Xiaohui Liu[SUP] 1 [/SUP], Qi Chen[SUP] 1 [/SUP], Yuxin Sun[SUP] 2 [/SUP], Yingying Su[SUP] 1 [/SUP], Shoujie Huang[SUP] 1 [/SUP], Ting Wu[SUP] 1 [/SUP], Ningshao Xia[SUP] 1 3 [/SUP]
Affiliations
- PMID: 35273584
- PMCID: PMC8902038
- DOI: 10.3389/fmicb.2022.828806
Abstract
The coronavirus disease 2019 (COVID-19) vaccines have very successfully decreased the disease risk as we know; some key information remains unknown due to the short development history and the lack of long-term follow-up studies in vaccinated populations. One of the unanswered issues is the protection duration conferred after COVID-19 vaccination, which appears to play a pivotal role in the future impact of pathogens and is critical to inform the public health response and policy decisions. Here, we review current information on the long-term effectiveness of different COVID-19 vaccines, persistence of immunogenicity, and gaps in knowledge. Meanwhile, we also discuss the influencing factors and future study prospects on this topic.
Keywords: COVID-19; SARS-CoV-2 variant; protection duration; vaccines; waning effectiveness.