tetano
Editor, Senior Moderator
Front Neurol
. 2020 Aug 21;11:909.
doi: 10.3389/fneur.2020.00909. eCollection 2020.
COVID-19 and Guillain-Barr? Syndrome: A Case Report and Review of Literature
Antonio Zito[SUP] 1 [/SUP], Enrico Alfonsi[SUP] 2 [/SUP], Diego Franciotta[SUP] 3 [/SUP], Massimiliano Todisco[SUP] 1 2 [/SUP], Matteo Gastaldi[SUP] 3 [/SUP], Matteo Cotta Ramusino[SUP] 1 4 [/SUP], Mauro Ceroni[SUP] 1 4 [/SUP], Alfredo Costa[SUP] 1 4 [/SUP]
Affiliations
Abstract
During the recent coronavirus disease 2019 (COVID-19) outbreak in Northern Italy, we observed a 57-year-old man developing acute motor-sensory axonal neuropathy, a variant of Guillain-Barr? syndrome (GBS), 12 days after severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. Similarly to other bacterial and viral infections, dysregulation of the immune system due to post-infectious mechanisms, such as the molecular mimicry, could lead to an indirect damage of the peripheral nervous system related to SARS-CoV-2. GBS causes motor dysfunctions that are not easily recognizable in non-neurological settings or in patients requiring ventilatory assistance. Several reports also suggested that GBS and Miller Fisher syndrome (MFS) could be neurological complications of COVID-19. Therefore, we performed a review of the 29 articles so far published, describing 33 GBS cases and five MFS cases associated with SARS-CoV-2 infection. We recommend awareness of this rare, but treatable, neurological syndrome, which may also determine a sudden and otherwise unexplained respiratory deterioration in COVID-19 patients.
Keywords: AMSAN; COVID-19; SARS-CoV-2; guillain–barr? syndrome; miller fisher syndrome; post-infectious.
. 2020 Aug 21;11:909.
doi: 10.3389/fneur.2020.00909. eCollection 2020.
COVID-19 and Guillain-Barr? Syndrome: A Case Report and Review of Literature
Antonio Zito[SUP] 1 [/SUP], Enrico Alfonsi[SUP] 2 [/SUP], Diego Franciotta[SUP] 3 [/SUP], Massimiliano Todisco[SUP] 1 2 [/SUP], Matteo Gastaldi[SUP] 3 [/SUP], Matteo Cotta Ramusino[SUP] 1 4 [/SUP], Mauro Ceroni[SUP] 1 4 [/SUP], Alfredo Costa[SUP] 1 4 [/SUP]
Affiliations
- PMID: 32973665
- PMCID: PMC7471770
- DOI: 10.3389/fneur.2020.00909
Abstract
During the recent coronavirus disease 2019 (COVID-19) outbreak in Northern Italy, we observed a 57-year-old man developing acute motor-sensory axonal neuropathy, a variant of Guillain-Barr? syndrome (GBS), 12 days after severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. Similarly to other bacterial and viral infections, dysregulation of the immune system due to post-infectious mechanisms, such as the molecular mimicry, could lead to an indirect damage of the peripheral nervous system related to SARS-CoV-2. GBS causes motor dysfunctions that are not easily recognizable in non-neurological settings or in patients requiring ventilatory assistance. Several reports also suggested that GBS and Miller Fisher syndrome (MFS) could be neurological complications of COVID-19. Therefore, we performed a review of the 29 articles so far published, describing 33 GBS cases and five MFS cases associated with SARS-CoV-2 infection. We recommend awareness of this rare, but treatable, neurological syndrome, which may also determine a sudden and otherwise unexplained respiratory deterioration in COVID-19 patients.
Keywords: AMSAN; COVID-19; SARS-CoV-2; guillain–barr? syndrome; miller fisher syndrome; post-infectious.