tetano
Editor, Senior Moderator
Front Trop Dis
. 2021 Nov 10;2:769330.
doi: 10.3389/fitd.2021.769330. eCollection 2021.
Case Report: First Confirmed Case of Coinfection of SARS-CoV-2 With Choclo orthohantavirus
Susana Hesse[SUP] 1 [/SUP], Heydy Nuñez[SUP] 2 3 [/SUP], Jacqueline R Salazar[SUP] 4 [/SUP], Tybbysay P Salinas[SUP] 4 [/SUP], Erika Barrera[SUP] 1 [/SUP], Ricardo Chong[SUP] 5 [/SUP], Saúl Torres[SUP] 3 [/SUP], Amarellys Cumbrera[SUP] 1 [/SUP], Idiamín Olivares[SUP] 1 [/SUP], Aimee Junco[SUP] 1 [/SUP], Christian Matteo[SUP] 1 [/SUP], Claudia González[SUP] 6 [/SUP], Oris Chavarría[SUP] 6 [/SUP], Ambar Moreno[SUP] 6 [/SUP], Jessica Góndola[SUP] 6 [/SUP], Leyda Ábrego[SUP] 7 8 [/SUP], Yamilka Díaz[SUP] 7 [/SUP], Yaneth Pitti[SUP] 7 [/SUP], Danilo Franco[SUP] 7 [/SUP], Mabel Martínez-Montero[SUP] 9 [/SUP], Juan Miguel Pascale[SUP] 6 8 [/SUP], Sandra López-Vergès[SUP] 7 8 [/SUP], Alexander A Martínez[SUP] 6 8 [/SUP], Blas Armién[SUP] 4 8 [/SUP]
Affiliations
Abstract
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a major international public health concern. The World Health Organization (WHO) declared the pandemic of coronavirus disease 2019 (COVID-19) on March 11, 2020. In Panama, the first SARS-CoV-2 infection was confirmed on March 9, 2020, and the first fatal case associated to COVID-19 was reported on March 10. This report presents the case of a 44-year-old female who arrived at the hospital with a respiratory failure, five days after the first fatal COVID-19 case, and who was living in a region where hantavirus pulmonary syndrome cases caused by Choclo orthohantavirus (CHOV), are prevalent. Thus, the clinical personnel set a differential diagnosis to determine a respiratory disease caused by the endemic CHOV or the new pandemic SARS-CoV-2. This case investigation describes the first coinfection by SARS-CoV-2 and CHOV worldwide. PCR detected both viruses during early stages of the disease and the genomic sequences were obtained. The presence of antibodies was determined during the patient's hospitalization. After 23 days at the intensive care unit, the patient survived with no sequelae, and antibodies against CHOV and SARS-CoV-2 were still detectable 12 months after the disease. The detection of the coinfection in this patient highlights the importance, during a pandemic, of complementing the testing and diagnosis of the emergent agent, SARS-CoV-2, with other common endemic respiratory pathogens and other zoonotic pathogens, like CHOV, in regions where they are of public health concern.
Keywords: COVID-19; Choclo orthohantavirus; SARS-CoV-2; case report; coinfection; hantavirus pulmonary syndrome.
. 2021 Nov 10;2:769330.
doi: 10.3389/fitd.2021.769330. eCollection 2021.
Case Report: First Confirmed Case of Coinfection of SARS-CoV-2 With Choclo orthohantavirus
Susana Hesse[SUP] 1 [/SUP], Heydy Nuñez[SUP] 2 3 [/SUP], Jacqueline R Salazar[SUP] 4 [/SUP], Tybbysay P Salinas[SUP] 4 [/SUP], Erika Barrera[SUP] 1 [/SUP], Ricardo Chong[SUP] 5 [/SUP], Saúl Torres[SUP] 3 [/SUP], Amarellys Cumbrera[SUP] 1 [/SUP], Idiamín Olivares[SUP] 1 [/SUP], Aimee Junco[SUP] 1 [/SUP], Christian Matteo[SUP] 1 [/SUP], Claudia González[SUP] 6 [/SUP], Oris Chavarría[SUP] 6 [/SUP], Ambar Moreno[SUP] 6 [/SUP], Jessica Góndola[SUP] 6 [/SUP], Leyda Ábrego[SUP] 7 8 [/SUP], Yamilka Díaz[SUP] 7 [/SUP], Yaneth Pitti[SUP] 7 [/SUP], Danilo Franco[SUP] 7 [/SUP], Mabel Martínez-Montero[SUP] 9 [/SUP], Juan Miguel Pascale[SUP] 6 8 [/SUP], Sandra López-Vergès[SUP] 7 8 [/SUP], Alexander A Martínez[SUP] 6 8 [/SUP], Blas Armién[SUP] 4 8 [/SUP]
Affiliations
- PMID: 34851327
- PMCID: PMC8594034
- DOI: 10.3389/fitd.2021.769330
Abstract
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a major international public health concern. The World Health Organization (WHO) declared the pandemic of coronavirus disease 2019 (COVID-19) on March 11, 2020. In Panama, the first SARS-CoV-2 infection was confirmed on March 9, 2020, and the first fatal case associated to COVID-19 was reported on March 10. This report presents the case of a 44-year-old female who arrived at the hospital with a respiratory failure, five days after the first fatal COVID-19 case, and who was living in a region where hantavirus pulmonary syndrome cases caused by Choclo orthohantavirus (CHOV), are prevalent. Thus, the clinical personnel set a differential diagnosis to determine a respiratory disease caused by the endemic CHOV or the new pandemic SARS-CoV-2. This case investigation describes the first coinfection by SARS-CoV-2 and CHOV worldwide. PCR detected both viruses during early stages of the disease and the genomic sequences were obtained. The presence of antibodies was determined during the patient's hospitalization. After 23 days at the intensive care unit, the patient survived with no sequelae, and antibodies against CHOV and SARS-CoV-2 were still detectable 12 months after the disease. The detection of the coinfection in this patient highlights the importance, during a pandemic, of complementing the testing and diagnosis of the emergent agent, SARS-CoV-2, with other common endemic respiratory pathogens and other zoonotic pathogens, like CHOV, in regions where they are of public health concern.
Keywords: COVID-19; Choclo orthohantavirus; SARS-CoV-2; case report; coinfection; hantavirus pulmonary syndrome.