tetano
Editor, Senior Moderator
Genes Dis. 2020 Apr 14. doi: 10.1016/j.gendis.2020.03.008. [Epub ahead of print]
The clinical and immunological features of pediatric COVID-19 patients in China.
Chen J[SUP]1[/SUP], Zhang ZZ[SUP]2[/SUP], Chen YK[SUP]3[/SUP], Long QX[SUP]1[/SUP], Tian WG[SUP]4[/SUP], Deng HJ[SUP]1[/SUP], Hu JL[SUP]1[/SUP], Zhang XX[SUP]5[/SUP], Pu-Liao[SUP]6[/SUP], Xiang JL[SUP]7[/SUP], Wang DX[SUP]8[/SUP], Hu P[SUP]1[/SUP], Zhou FC[SUP]9[/SUP], Li ZJ[SUP]5[/SUP], Xu HM[SUP]2[/SUP], Cai XF[SUP]1[/SUP], Wang DQ[SUP]1[/SUP], Hu Y[SUP]1[/SUP], Tang N[SUP]1[/SUP], Liu BZ[SUP]10[/SUP], Wu GC[SUP]11[/SUP], Huang AL[SUP]1[/SUP].
Author information
Abstract
In December 2019, the corona virus disease 2019 (COVID-19) caused by novel coronavirus (SARS-CoV-2) emerged in Wuhan, China and rapidly spread worldwide. Few information on clinical features and immunological profile of COVID-19 in paediatrics. The clinical features and treatment outcomes of twelve paediatric patients confirmed as COVID-19 were analyzed. The immunological features of children patients was investigated and compared with twenty adult patients. The median age was 14.5-years (range from 0.64 to 17), and six of the patients were male. The average incubation period was 8 days. Clinically, cough (9/12, 75%) and fever (7/12, 58.3%) were the most common symptoms. Four patients (33.3%) had diarrhea during the disease. As to the immune profile, children had higher amount of total T cell, CD8+ T cell and B cell but lower CRP levels than adults (P < 0.05). Ground-glass opacity (GGO) and local patchy shadowing were the typical radiological findings on chest CT scan. All patients received antiviral and symptomatic treatment and the symptom relieved in 3-4 days after admitted to hospital. The paediatric patients showed mild symptom but with longer incubation period. Children infected with SARS-CoV-2 had different immune profile with higher T cell amount and low inflammatory factors level, which might ascribed to the mild clinical symptom. We advise that nucleic acid test or examination of serum IgM/IgG antibodies against SARS-CoV-2 should be taken for children with exposure history regardless of clinical symptom.
? 2020 Chongqing Medical University. Production and hosting by Elsevier B.V.
KEYWORDS:
COVID-19; Clinical features; Immune; Paediatrics; SARS-CoV-2
PMID:32363222PMCID:PMC7194810DOI:10.1016/j.gendis.2020.03.008
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The clinical and immunological features of pediatric COVID-19 patients in China.
Chen J[SUP]1[/SUP], Zhang ZZ[SUP]2[/SUP], Chen YK[SUP]3[/SUP], Long QX[SUP]1[/SUP], Tian WG[SUP]4[/SUP], Deng HJ[SUP]1[/SUP], Hu JL[SUP]1[/SUP], Zhang XX[SUP]5[/SUP], Pu-Liao[SUP]6[/SUP], Xiang JL[SUP]7[/SUP], Wang DX[SUP]8[/SUP], Hu P[SUP]1[/SUP], Zhou FC[SUP]9[/SUP], Li ZJ[SUP]5[/SUP], Xu HM[SUP]2[/SUP], Cai XF[SUP]1[/SUP], Wang DQ[SUP]1[/SUP], Hu Y[SUP]1[/SUP], Tang N[SUP]1[/SUP], Liu BZ[SUP]10[/SUP], Wu GC[SUP]11[/SUP], Huang AL[SUP]1[/SUP].
Author information
Abstract
In December 2019, the corona virus disease 2019 (COVID-19) caused by novel coronavirus (SARS-CoV-2) emerged in Wuhan, China and rapidly spread worldwide. Few information on clinical features and immunological profile of COVID-19 in paediatrics. The clinical features and treatment outcomes of twelve paediatric patients confirmed as COVID-19 were analyzed. The immunological features of children patients was investigated and compared with twenty adult patients. The median age was 14.5-years (range from 0.64 to 17), and six of the patients were male. The average incubation period was 8 days. Clinically, cough (9/12, 75%) and fever (7/12, 58.3%) were the most common symptoms. Four patients (33.3%) had diarrhea during the disease. As to the immune profile, children had higher amount of total T cell, CD8+ T cell and B cell but lower CRP levels than adults (P < 0.05). Ground-glass opacity (GGO) and local patchy shadowing were the typical radiological findings on chest CT scan. All patients received antiviral and symptomatic treatment and the symptom relieved in 3-4 days after admitted to hospital. The paediatric patients showed mild symptom but with longer incubation period. Children infected with SARS-CoV-2 had different immune profile with higher T cell amount and low inflammatory factors level, which might ascribed to the mild clinical symptom. We advise that nucleic acid test or examination of serum IgM/IgG antibodies against SARS-CoV-2 should be taken for children with exposure history regardless of clinical symptom.
? 2020 Chongqing Medical University. Production and hosting by Elsevier B.V.
KEYWORDS:
COVID-19; Clinical features; Immune; Paediatrics; SARS-CoV-2
PMID:32363222PMCID:PMC7194810DOI:10.1016/j.gendis.2020.03.008
Free full text