Genetics, receptor binding, and virulence in mice of H10N8 influenza viruses isolated from ducks and chickens in live poultry markets in China

[tetano]

J Virol. 2015 Apr 8. pii: JVI.00017-15. [Epub ahead of print]
[h=1]Genetics, receptor binding, and virulence in mice of H10N8 influenza viruses isolated from ducks and chickens in live poultry markets in China.[/h] Deng G[SUP]1[/SUP], Shi J[SUP]1[/SUP], Wang J[SUP]1[/SUP], Kong H[SUP]1[/SUP], Cui P[SUP]1[/SUP], Zhang F[SUP]1[/SUP], Tan D[SUP]1[/SUP], Suzuki Y[SUP]2[/SUP], Liu L[SUP]1[/SUP], Jiang Y[SUP]1[/SUP], Guan Y[SUP]1[/SUP], Chen H[SUP]3[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] We analyzed eight H10N8 viruses isolated from ducks and chickens in live poultry markets from 2009 to 2013 in China. These viruses showed distinct genetic diversity and formed five genotypes: the four duck isolates formed four different genotypes, whereas the four chicken viruses belong to a single genotype. The viruses bound to both human- and avian-type receptors, and four of the viruses caused 12.7% - 22.5% body weight loss in mice.
Copyright ? 2015, American Society for Microbiology. All Rights Reserved.


PMID: 25855738 [PubMed - as supplied by publisher] Free full text