tetano
Editor, Senior Moderator
Genomics
. 2020 Aug 18;S0888-7543(20)30896-X.
doi: 10.1016/j.ygeno.2020.08.021. Online ahead of print.
Missense mutations in SARS-CoV2 genomes from Indian patients
Sk Sarif Hassan[SUP] 1 [/SUP], Pabitra Pal Choudhury[SUP] 2 [/SUP], Bidyut Roy[SUP] 3 [/SUP], Siddhartha Sankar Jana[SUP] 4 [/SUP]
Affiliations
Abstract
The genetic diversity of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) in several countries sums up a large fraction of its worldwide genetic diversity. In this present study, variations in terms of missense mutations among the SARS-CoV2 genomes from 128 Indian patients, as of May 2020, are accounted and thereby some key findings with some hypotheses were made. These mutations across various genes of these genomes show wide genetic variations in sequence and rapid evolution of SARS-CoV2 virus. The presence of unique mutations in the studied SARS-CoV2 genomes has led to their attenuation. Few Genes such as ORF6, ORF10 are free from any mutations in the Indian context of 339 genomes observed as of 14th July 2020. Further, E protein contains only one mutation. This may suggest that designing a therapeutic approach against ORF6, ORF10 and E genes may have a beneficial effect in controlling COVID-19 pandemic especially in India.
Keywords: Indian patients; Missense mutations and genetic variations; SARS-CoV2 genomes; Therapeutic target.
. 2020 Aug 18;S0888-7543(20)30896-X.
doi: 10.1016/j.ygeno.2020.08.021. Online ahead of print.
Missense mutations in SARS-CoV2 genomes from Indian patients
Sk Sarif Hassan[SUP] 1 [/SUP], Pabitra Pal Choudhury[SUP] 2 [/SUP], Bidyut Roy[SUP] 3 [/SUP], Siddhartha Sankar Jana[SUP] 4 [/SUP]
Affiliations
- PMID: 32822756
- DOI: 10.1016/j.ygeno.2020.08.021
Abstract
The genetic diversity of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) in several countries sums up a large fraction of its worldwide genetic diversity. In this present study, variations in terms of missense mutations among the SARS-CoV2 genomes from 128 Indian patients, as of May 2020, are accounted and thereby some key findings with some hypotheses were made. These mutations across various genes of these genomes show wide genetic variations in sequence and rapid evolution of SARS-CoV2 virus. The presence of unique mutations in the studied SARS-CoV2 genomes has led to their attenuation. Few Genes such as ORF6, ORF10 are free from any mutations in the Indian context of 339 genomes observed as of 14th July 2020. Further, E protein contains only one mutation. This may suggest that designing a therapeutic approach against ORF6, ORF10 and E genes may have a beneficial effect in controlling COVID-19 pandemic especially in India.
Keywords: Indian patients; Missense mutations and genetic variations; SARS-CoV2 genomes; Therapeutic target.