tetano
Editor, Senior Moderator
Gut Microbes
. 2023 Dec;15(2):2249146.
doi: 10.1080/19490976.2023.2249146. Gut microbiota from patients with COVID-19 cause alterations in mice that resemble post-COVID symptoms
Viviani Mendes de Almeida[SUP] 1 [/SUP], Daiane F Engel[SUP] 2 [/SUP], Mayra F Ricci[SUP] 1 [/SUP], Clênio Silva Cruz[SUP] 1 [/SUP], Ícaro Santos Lopes[SUP] 3 [/SUP], Daniele Almeida Alves[SUP] 4 [/SUP], Mirna d' Auriol[SUP] 5 [/SUP], João Magalhães[SUP] 1 [/SUP], Elayne C Machado[SUP] 1 [/SUP], Victor M Rocha[SUP] 1 [/SUP], Toniana G Carvalho[SUP] 6 [/SUP], Larisse S B Lacerda[SUP] 7 [/SUP], Jordane C Pimenta[SUP] 7 [/SUP], Mariana Aganetti[SUP] 1 [/SUP], Giuliana S Zuccoli[SUP] 8 [/SUP], Bradley J Smith[SUP] 8 [/SUP], Victor C Carregari[SUP] 8 [/SUP], Erika da Silva Rosa[SUP] 1 [/SUP], Izabela Galvão[SUP] 1 [/SUP], Geovanni Dantas Cassali[SUP] 9 [/SUP], Cristiana C Garcia[SUP] 10 [/SUP], Mauro Martins Teixeira[SUP] 7 [/SUP], Leiliane C André[SUP] 5 [/SUP], Fabiola Mara Ribeiro[SUP] 6 [/SUP], Flaviano S Martins[SUP] 11 [/SUP], Rafael Simone Saia[SUP] 12 [/SUP], Vivian Vasconcelos Costa[SUP] 7 [/SUP], Daniel Martins-de-Souza[SUP] 8 13 14 15 [/SUP], Philip M Hansbro[SUP] 16 [/SUP], João Trindade Marques[SUP] 4 17 [/SUP], Eric R G R Aguiar[SUP] 3 [/SUP], Angélica T Vieira[SUP] 1 [/SUP]
Affiliations
Long-term sequelae of coronavirus disease (COVID)-19 are frequent and of major concern. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection affects the host gut microbiota, which is linked to disease severity in patients with COVID-19. Here, we report that the gut microbiota of post-COVID subjects had a remarkable predominance of Enterobacteriaceae strains with an antibiotic-resistant phenotype compared to healthy controls. Additionally, short-chain fatty acid (SCFA) levels were reduced in feces. Fecal transplantation from post-COVID subjects to germ-free mice led to lung inflammation and worse outcomes during pulmonary infection by multidrug-resistant Klebsiella pneumoniae. transplanted mice also exhibited poor cognitive performance. Overall, we show prolonged impacts of SARS-CoV-2 infection on the gut microbiota that persist after subjects have cleared the virus. Together, these data demonstrate that the gut microbiota can directly contribute to post-COVID sequelae, suggesting that it may be a potential therapeutic target.
Keywords: COVID-19; SARS-CoV-2; antimicrobial-resistance; inflammation; microbiota; post-COVID.
. 2023 Dec;15(2):2249146.
doi: 10.1080/19490976.2023.2249146. Gut microbiota from patients with COVID-19 cause alterations in mice that resemble post-COVID symptoms
Viviani Mendes de Almeida[SUP] 1 [/SUP], Daiane F Engel[SUP] 2 [/SUP], Mayra F Ricci[SUP] 1 [/SUP], Clênio Silva Cruz[SUP] 1 [/SUP], Ícaro Santos Lopes[SUP] 3 [/SUP], Daniele Almeida Alves[SUP] 4 [/SUP], Mirna d' Auriol[SUP] 5 [/SUP], João Magalhães[SUP] 1 [/SUP], Elayne C Machado[SUP] 1 [/SUP], Victor M Rocha[SUP] 1 [/SUP], Toniana G Carvalho[SUP] 6 [/SUP], Larisse S B Lacerda[SUP] 7 [/SUP], Jordane C Pimenta[SUP] 7 [/SUP], Mariana Aganetti[SUP] 1 [/SUP], Giuliana S Zuccoli[SUP] 8 [/SUP], Bradley J Smith[SUP] 8 [/SUP], Victor C Carregari[SUP] 8 [/SUP], Erika da Silva Rosa[SUP] 1 [/SUP], Izabela Galvão[SUP] 1 [/SUP], Geovanni Dantas Cassali[SUP] 9 [/SUP], Cristiana C Garcia[SUP] 10 [/SUP], Mauro Martins Teixeira[SUP] 7 [/SUP], Leiliane C André[SUP] 5 [/SUP], Fabiola Mara Ribeiro[SUP] 6 [/SUP], Flaviano S Martins[SUP] 11 [/SUP], Rafael Simone Saia[SUP] 12 [/SUP], Vivian Vasconcelos Costa[SUP] 7 [/SUP], Daniel Martins-de-Souza[SUP] 8 13 14 15 [/SUP], Philip M Hansbro[SUP] 16 [/SUP], João Trindade Marques[SUP] 4 17 [/SUP], Eric R G R Aguiar[SUP] 3 [/SUP], Angélica T Vieira[SUP] 1 [/SUP]
Affiliations
- PMID: 37668317
- DOI: 10.1080/19490976.2023.2249146
Long-term sequelae of coronavirus disease (COVID)-19 are frequent and of major concern. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection affects the host gut microbiota, which is linked to disease severity in patients with COVID-19. Here, we report that the gut microbiota of post-COVID subjects had a remarkable predominance of Enterobacteriaceae strains with an antibiotic-resistant phenotype compared to healthy controls. Additionally, short-chain fatty acid (SCFA) levels were reduced in feces. Fecal transplantation from post-COVID subjects to germ-free mice led to lung inflammation and worse outcomes during pulmonary infection by multidrug-resistant Klebsiella pneumoniae. transplanted mice also exhibited poor cognitive performance. Overall, we show prolonged impacts of SARS-CoV-2 infection on the gut microbiota that persist after subjects have cleared the virus. Together, these data demonstrate that the gut microbiota can directly contribute to post-COVID sequelae, suggesting that it may be a potential therapeutic target.
Keywords: COVID-19; SARS-CoV-2; antimicrobial-resistance; inflammation; microbiota; post-COVID.