tetano
Editor, Senior Moderator
Health Sci Rep
. 2022 Feb 15;5(2):e510.
doi: 10.1002/hsr2.510. eCollection 2022 Mar.
Prenatal and neonatal complications of COVID-19: A systematic review
Zahra Pashaei[SUP] 1 [/SUP], SeyedAhmad SeyedAlinaghi[SUP] 1 [/SUP], Kowsar Qaderi[SUP] 2 [/SUP], Alireza Barzegary[SUP] 3 [/SUP], Amirali Karimi[SUP] 4 [/SUP], Seyed Peyman Mirghaderi[SUP] 4 [/SUP], Pegah Mirzapour[SUP] 1 [/SUP], Marcarious M Tantuoyir[SUP] 1 5 [/SUP], Omid Dadras[SUP] 6 [/SUP], Zoha Ali[SUP] 1 [/SUP], Fabricio Voltarelli[SUP] 7 [/SUP], Esmaeil Mehraeen[SUP] 8 [/SUP]
Affiliations
Abstract
Background and aims: The outbreak of coronavirus disease 2019 (COVID-19) over the past year has affected public health worldwide. During pregnancy, the maternal immune system and inflammatory responses are widely suppressed. Pregnancy-related immune system suppression could make the mother vulnerable to infectious diseases like SARS-COV-2. However, current data suggest little to no possibility of COVID-19 transmission in pregnant women to the fetus during pregnancy or childbirth. This systematic review focused on the possible complications of COVID-19 infection in the fetus and newborn babies including the possibility and evidence of vertical transmission by reviewing articles published during the first year of the COVID-19 pandemic.
Methods: We conducted a systematic search using keywords on PubMed, Embase, and Scopus databases. The studies followed a title/abstract and a full-text screening process, and the eligible articles were included in the study.
Results: In total, 238 published papers were identified using a systematic search strategy (44 articles met the inclusion criteria and were included in the final review). In all studies, a total of 2375 women with signs and symptoms of COVID-19, who were in the second and third trimester of pregnancy, were assessed mild to moderate pneumonia was one of the most common symptoms. Seventy-three percent of the women did not present any comorbidity, 19% had a fever, 17% had to cough as the most frequent clinical signs and symptoms, 7.5% had pulmonary changes with chest scans, 8% had increased C reactive protein, and 9.4% had decreased lymphocytes (lymphocytopenia). A total of 2716 newborns and fetal were assessed; the delivery method of 1725 of them was reported, 913 (53%) through C-section delivery, and 812 through normal vaginal delivery (47%). Of total newborns, 13 died (five died along with the mother), and 1965 were tested for SARS-CoV-2:118 tested positive. In a study, vertical transmission in seven cases was reported in total of 145 cases assessed.
Conclusion: It appeared that most pregnant COVID patients were mildly ill, and there is currently no convincing evidence to support the vertical transmission of COVID-19 disease. Therefore, neonates do not represent any additional risk for adverse outcomes neither during the prenatal period nor after birth.
Keywords: COVID‐19; SARS‐CoV‐2; fetus; neonatal; newborn; prenatal.
. 2022 Feb 15;5(2):e510.
doi: 10.1002/hsr2.510. eCollection 2022 Mar.
Prenatal and neonatal complications of COVID-19: A systematic review
Zahra Pashaei[SUP] 1 [/SUP], SeyedAhmad SeyedAlinaghi[SUP] 1 [/SUP], Kowsar Qaderi[SUP] 2 [/SUP], Alireza Barzegary[SUP] 3 [/SUP], Amirali Karimi[SUP] 4 [/SUP], Seyed Peyman Mirghaderi[SUP] 4 [/SUP], Pegah Mirzapour[SUP] 1 [/SUP], Marcarious M Tantuoyir[SUP] 1 5 [/SUP], Omid Dadras[SUP] 6 [/SUP], Zoha Ali[SUP] 1 [/SUP], Fabricio Voltarelli[SUP] 7 [/SUP], Esmaeil Mehraeen[SUP] 8 [/SUP]
Affiliations
- PMID: 35224216
- PMCID: PMC8844871
- DOI: 10.1002/hsr2.510
Abstract
Background and aims: The outbreak of coronavirus disease 2019 (COVID-19) over the past year has affected public health worldwide. During pregnancy, the maternal immune system and inflammatory responses are widely suppressed. Pregnancy-related immune system suppression could make the mother vulnerable to infectious diseases like SARS-COV-2. However, current data suggest little to no possibility of COVID-19 transmission in pregnant women to the fetus during pregnancy or childbirth. This systematic review focused on the possible complications of COVID-19 infection in the fetus and newborn babies including the possibility and evidence of vertical transmission by reviewing articles published during the first year of the COVID-19 pandemic.
Methods: We conducted a systematic search using keywords on PubMed, Embase, and Scopus databases. The studies followed a title/abstract and a full-text screening process, and the eligible articles were included in the study.
Results: In total, 238 published papers were identified using a systematic search strategy (44 articles met the inclusion criteria and were included in the final review). In all studies, a total of 2375 women with signs and symptoms of COVID-19, who were in the second and third trimester of pregnancy, were assessed mild to moderate pneumonia was one of the most common symptoms. Seventy-three percent of the women did not present any comorbidity, 19% had a fever, 17% had to cough as the most frequent clinical signs and symptoms, 7.5% had pulmonary changes with chest scans, 8% had increased C reactive protein, and 9.4% had decreased lymphocytes (lymphocytopenia). A total of 2716 newborns and fetal were assessed; the delivery method of 1725 of them was reported, 913 (53%) through C-section delivery, and 812 through normal vaginal delivery (47%). Of total newborns, 13 died (five died along with the mother), and 1965 were tested for SARS-CoV-2:118 tested positive. In a study, vertical transmission in seven cases was reported in total of 145 cases assessed.
Conclusion: It appeared that most pregnant COVID patients were mildly ill, and there is currently no convincing evidence to support the vertical transmission of COVID-19 disease. Therefore, neonates do not represent any additional risk for adverse outcomes neither during the prenatal period nor after birth.
Keywords: COVID‐19; SARS‐CoV‐2; fetus; neonatal; newborn; prenatal.