tetano
Editor, Senior Moderator
Heart
. 2020 May 25;heartjnl-2020-316909.
doi: 10.1136/heartjnl-2020-316909. Online ahead of print.
Do Underlying Cardiovascular Diseases Have Any Impact on Hospitalised Patients With COVID-19?
Jixiang Zhang[SUP] #[/SUP][SUP] 1 [/SUP], Shimin Lu[SUP] #[/SUP][SUP] 1 [/SUP], Xiaoli Wang[SUP] 2 [/SUP], Xuemei Jia[SUP] 1 [/SUP], Jiao Li[SUP] 1 [/SUP], Hongbo Lei[SUP] 3 [/SUP], Zhengru Liu[SUP] 1 [/SUP], Fei Liao[SUP] 1 [/SUP], Mengyao Ji[SUP] 1 [/SUP], Xiaoguang Lv[SUP] 1 [/SUP], Jian Kang[SUP] 1 [/SUP], Shan Tian[SUP] 1 [/SUP], Jingjing Ma[SUP] 4 [/SUP], Dandan Wu[SUP] 5 [/SUP], Yang Gong[SUP] 6 [/SUP], Yu Xu[SUP] 7 [/SUP], Weiguo Dong[SUP] 8 [/SUP]
Affiliations
Abstract
Objectives: An outbreak of the highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has sickened thousands of people in China. The purpose of this study was to explore the early clinical characteristics of COVID-19 patients with cardiovascular disease (CVD).
Methods: This is a retrospective analysis of patients with COVID-19 from a single centre. All patients underwent real-time reverse transcription PCR for SARS-CoV-2 on admission. Demographic and clinical factors and laboratory data were reviewed and collected to evaluate for significant associations.
Results: The study included 541 patients with COVID-19. A total of 144 (26.6%) patients had a history of CVD. The mortality of patients with CVD reached 22.2%, which was higher than that of the overall population of this study (9.8%). Patients with CVD were also more likely to develop liver function abnormality, elevated blood creatinine and lactic dehydrogenase (p<0.05). Symptoms of sputum production were more common in patients with CVD (p=0.026). Lymphocytes, haemoglobin and albumin below the normal range were pervasive in the CVD group (p<0.05). The proportion of critically ill patients in the CVD group (27.8%) was significantly higher than that in the non-CVD group (8.8%). Multivariable logistic regression analysis revealed that CVD (OR: 2.735 (95% CI 1.495 to 5.003), p=0.001) was associated with critical COVID-19 condition, while patients with coronary heart disease were less likely to reach recovery standards (OR: 0.331 (95% CI 0.125 to 0.880), p=0.027).
Conclusions: Considering the high prevalence of CVD, a thorough CVD assessment at diagnosis and early intervention are recommended in COVID-19 patients with CVD. Patients with CVD are more vulnerable to deterioration.
Keywords: cardiac rehabilitation; cardiac risk factors and prevention; electronic medical records; hypertension.
. 2020 May 25;heartjnl-2020-316909.
doi: 10.1136/heartjnl-2020-316909. Online ahead of print.
Do Underlying Cardiovascular Diseases Have Any Impact on Hospitalised Patients With COVID-19?
Jixiang Zhang[SUP] #[/SUP][SUP] 1 [/SUP], Shimin Lu[SUP] #[/SUP][SUP] 1 [/SUP], Xiaoli Wang[SUP] 2 [/SUP], Xuemei Jia[SUP] 1 [/SUP], Jiao Li[SUP] 1 [/SUP], Hongbo Lei[SUP] 3 [/SUP], Zhengru Liu[SUP] 1 [/SUP], Fei Liao[SUP] 1 [/SUP], Mengyao Ji[SUP] 1 [/SUP], Xiaoguang Lv[SUP] 1 [/SUP], Jian Kang[SUP] 1 [/SUP], Shan Tian[SUP] 1 [/SUP], Jingjing Ma[SUP] 4 [/SUP], Dandan Wu[SUP] 5 [/SUP], Yang Gong[SUP] 6 [/SUP], Yu Xu[SUP] 7 [/SUP], Weiguo Dong[SUP] 8 [/SUP]
Affiliations
- PMID: 32451362
- DOI: 10.1136/heartjnl-2020-316909
Abstract
Objectives: An outbreak of the highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has sickened thousands of people in China. The purpose of this study was to explore the early clinical characteristics of COVID-19 patients with cardiovascular disease (CVD).
Methods: This is a retrospective analysis of patients with COVID-19 from a single centre. All patients underwent real-time reverse transcription PCR for SARS-CoV-2 on admission. Demographic and clinical factors and laboratory data were reviewed and collected to evaluate for significant associations.
Results: The study included 541 patients with COVID-19. A total of 144 (26.6%) patients had a history of CVD. The mortality of patients with CVD reached 22.2%, which was higher than that of the overall population of this study (9.8%). Patients with CVD were also more likely to develop liver function abnormality, elevated blood creatinine and lactic dehydrogenase (p<0.05). Symptoms of sputum production were more common in patients with CVD (p=0.026). Lymphocytes, haemoglobin and albumin below the normal range were pervasive in the CVD group (p<0.05). The proportion of critically ill patients in the CVD group (27.8%) was significantly higher than that in the non-CVD group (8.8%). Multivariable logistic regression analysis revealed that CVD (OR: 2.735 (95% CI 1.495 to 5.003), p=0.001) was associated with critical COVID-19 condition, while patients with coronary heart disease were less likely to reach recovery standards (OR: 0.331 (95% CI 0.125 to 0.880), p=0.027).
Conclusions: Considering the high prevalence of CVD, a thorough CVD assessment at diagnosis and early intervention are recommended in COVID-19 patients with CVD. Patients with CVD are more vulnerable to deterioration.
Keywords: cardiac rehabilitation; cardiac risk factors and prevention; electronic medical records; hypertension.