tetano
Editor, Senior Moderator
Heart Views
. Jan-Mar 2021;22(1):20-26.
doi: 10.4103/HEARTVIEWS.HEARTVIEWS_224_20. Epub 2021 Apr 22.
Cardiovascular Manifestations and Outcomes in Patients Admitted with Severe COVID-19: Middle Eastern Country Multicenter Data
Fahad Alkindi[SUP] 1 [/SUP], Khamis Alhashmi[SUP] 2 [/SUP], Sunil Nadar[SUP] 1 [/SUP], Salma Alharthi[SUP] 3 [/SUP], Khalid Alsaidi[SUP] 4 [/SUP], Tasneem Alrashdi[SUP] 4 [/SUP], Shabib Alasmi[SUP] 4 [/SUP], Feryal Khamis[SUP] 4 [/SUP], Adil Algafri[SUP] 5 [/SUP], Sultan Allawati[SUP] 5 [/SUP], Muzna Alfarsi[SUP] 5 [/SUP], Sathiya Murthi[SUP] 3 [/SUP], Mujahid Albusaidi[SUP] 1 [/SUP], Abdullah Balkhair[SUP] 1 [/SUP], Hafidh Alhadi[SUP] 1 [/SUP], Khalid Alrasadi[SUP] 2 [/SUP], Maather Alabri[SUP] 2 [/SUP], Maryam Alissai[SUP] 2 [/SUP], Shihab Alkindi[SUP] 2 [/SUP], Hilal Alsabti[SUP] 2 [/SUP]
Affiliations
Abstract
Objectives: Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory distress syndrome-coronavirus-2 (SARS-CoV-2) -that can affect the cardiovascular system. The aim of our study was to assess the cardiovascular manifestations and its effect on the overall mortality among patients with severe COVID-19 who were admitted in the intensive care units (ICU).
Methods: This is a retrospective, multicenter cohort study that included all adult patients admitted to the ICU with laboratory-confirmed COVID-19 in three major hospitals in Oman between March 1, 2020, and August 10, 2020.
Results: A total of 541 patients (mean age of 50.57 ± 15.57 years; 401 [74.1%] male) were included in the study of which 452 (83.5%) were discharged and 89 (16.5%) died during hospitalization.Evidence of cardiac involvement was found in 185 (34.2%) patients, which included raised troponin (31.6%), arrhythmias (4.3%), myocardial infarctions (2.6%), or drop in ejection fraction (0.9%). High troponin of >100 ng/l was associated with higher mortality (odds ratio [OR] = 7.98; 95% confidence interval [CI]: 4.20-15.15); P < 0.001). Patients with any cardiovascular involvement also had a high risk of dying (OR = 8.8; 95% CI: 4.6-16.5; P < 0.001).
Conclusion: Almost a third of patients in our study had evidence of cardiovascular involvement which was mainly myocardial injury. This was associated with increased mortality.
Keywords: COVID-19; Cardiovascular manifestations; SARS-CoV-2; mortality; troponin.
. Jan-Mar 2021;22(1):20-26.
doi: 10.4103/HEARTVIEWS.HEARTVIEWS_224_20. Epub 2021 Apr 22.
Cardiovascular Manifestations and Outcomes in Patients Admitted with Severe COVID-19: Middle Eastern Country Multicenter Data
Fahad Alkindi[SUP] 1 [/SUP], Khamis Alhashmi[SUP] 2 [/SUP], Sunil Nadar[SUP] 1 [/SUP], Salma Alharthi[SUP] 3 [/SUP], Khalid Alsaidi[SUP] 4 [/SUP], Tasneem Alrashdi[SUP] 4 [/SUP], Shabib Alasmi[SUP] 4 [/SUP], Feryal Khamis[SUP] 4 [/SUP], Adil Algafri[SUP] 5 [/SUP], Sultan Allawati[SUP] 5 [/SUP], Muzna Alfarsi[SUP] 5 [/SUP], Sathiya Murthi[SUP] 3 [/SUP], Mujahid Albusaidi[SUP] 1 [/SUP], Abdullah Balkhair[SUP] 1 [/SUP], Hafidh Alhadi[SUP] 1 [/SUP], Khalid Alrasadi[SUP] 2 [/SUP], Maather Alabri[SUP] 2 [/SUP], Maryam Alissai[SUP] 2 [/SUP], Shihab Alkindi[SUP] 2 [/SUP], Hilal Alsabti[SUP] 2 [/SUP]
Affiliations
- PMID: 34276884
- PMCID: PMC8254152
- DOI: 10.4103/HEARTVIEWS.HEARTVIEWS_224_20
Abstract
Objectives: Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory distress syndrome-coronavirus-2 (SARS-CoV-2) -that can affect the cardiovascular system. The aim of our study was to assess the cardiovascular manifestations and its effect on the overall mortality among patients with severe COVID-19 who were admitted in the intensive care units (ICU).
Methods: This is a retrospective, multicenter cohort study that included all adult patients admitted to the ICU with laboratory-confirmed COVID-19 in three major hospitals in Oman between March 1, 2020, and August 10, 2020.
Results: A total of 541 patients (mean age of 50.57 ± 15.57 years; 401 [74.1%] male) were included in the study of which 452 (83.5%) were discharged and 89 (16.5%) died during hospitalization.Evidence of cardiac involvement was found in 185 (34.2%) patients, which included raised troponin (31.6%), arrhythmias (4.3%), myocardial infarctions (2.6%), or drop in ejection fraction (0.9%). High troponin of >100 ng/l was associated with higher mortality (odds ratio [OR] = 7.98; 95% confidence interval [CI]: 4.20-15.15); P < 0.001). Patients with any cardiovascular involvement also had a high risk of dying (OR = 8.8; 95% CI: 4.6-16.5; P < 0.001).
Conclusion: Almost a third of patients in our study had evidence of cardiovascular involvement which was mainly myocardial injury. This was associated with increased mortality.
Keywords: COVID-19; Cardiovascular manifestations; SARS-CoV-2; mortality; troponin.