tetano
Editor, Senior Moderator
Heliyon
. 2023 Feb 17;e13801.
doi: 10.1016/j.heliyon.2023.e13801. Online ahead of print.
Decoding the bidirectional relationship between gut microbiota and COVID-19
Tanya Ralli[SUP] 1 [/SUP], Zoya Saifi[SUP] 1 [/SUP], Anjali Rathee[SUP] 2 [/SUP], Vidhu Aeri[SUP] 3 [/SUP], Kanchan Kohli[SUP] 1 4 [/SUP]
Affiliations
Abstract
From late 2019, whole world has been facing COVID-19 pandemic which is caused by SARS-CoV-2 virus. This virus primarily attacks the respiratory tract and enter host cell by binding with angiotensin 2 converting enzyme receptors present on alveoli of the lungs. Despite its binding in the lungs, many patients have reported gastrointestinal symptoms and indeed, RNA of the virus have been found in faecal sample of patients. This observation gave a clue of the involvement of gut-lung axis in this disease development and progression. From several studies reported in past two years, intestinal microbiome has shown to have bidirectional link with lungs i.e., gut dysbiosis increases the tendency of infection with COVID-19 and coronavirus can also cause perturbations in intestinal microbial composition. Thus, in this review we have tried to figure out the mechanisms by which disturbances in the gut composition can increase the susceptibility to COVID-19. Understanding these mechanisms can play a crucial role in decreasing the disease outcomes by manipulating the gut microbiome using prebiotics, probiotics, or combination of two. Even, faecal microbiota transplantation can also show better results, but intensive clinical trials need to be done first.
Keywords: ACE2; COVID-19; Coronavirus; Gut lung axis; Gut microbiome.
. 2023 Feb 17;e13801.
doi: 10.1016/j.heliyon.2023.e13801. Online ahead of print.
Decoding the bidirectional relationship between gut microbiota and COVID-19
Tanya Ralli[SUP] 1 [/SUP], Zoya Saifi[SUP] 1 [/SUP], Anjali Rathee[SUP] 2 [/SUP], Vidhu Aeri[SUP] 3 [/SUP], Kanchan Kohli[SUP] 1 4 [/SUP]
Affiliations
- PMID: 36811017
- PMCID: PMC9936796
- DOI: 10.1016/j.heliyon.2023.e13801
Abstract
From late 2019, whole world has been facing COVID-19 pandemic which is caused by SARS-CoV-2 virus. This virus primarily attacks the respiratory tract and enter host cell by binding with angiotensin 2 converting enzyme receptors present on alveoli of the lungs. Despite its binding in the lungs, many patients have reported gastrointestinal symptoms and indeed, RNA of the virus have been found in faecal sample of patients. This observation gave a clue of the involvement of gut-lung axis in this disease development and progression. From several studies reported in past two years, intestinal microbiome has shown to have bidirectional link with lungs i.e., gut dysbiosis increases the tendency of infection with COVID-19 and coronavirus can also cause perturbations in intestinal microbial composition. Thus, in this review we have tried to figure out the mechanisms by which disturbances in the gut composition can increase the susceptibility to COVID-19. Understanding these mechanisms can play a crucial role in decreasing the disease outcomes by manipulating the gut microbiome using prebiotics, probiotics, or combination of two. Even, faecal microbiota transplantation can also show better results, but intensive clinical trials need to be done first.
Keywords: ACE2; COVID-19; Coronavirus; Gut lung axis; Gut microbiome.