tetano
Editor, Senior Moderator
Heliyon
. 2020 Dec;6(12):e05635.
doi: 10.1016/j.heliyon.2020.e05635. Epub 2020 Nov 30.
Proteins from SARS-CoV-2 reduce T cell proliferation: A mirror image of sepsis
Jos? Avenda?o-Ortiz[SUP] 1 2 [/SUP], Roberto Lozano-Rodr?guez[SUP] 1 2 [/SUP], Alejandro Mart?n-Quir?s[SUP] 3 [/SUP], Charbel Maroun-Eid[SUP] 1 [/SUP], Ver?nica Terr?n[SUP] 1 2 [/SUP], Jaime Valent?n[SUP] 1 2 [/SUP], Karla Montalb?n-Hern?ndez[SUP] 1 2 [/SUP], F?tima Ruiz de la Bastida[SUP] 1 2 [/SUP], Miguel A Garc?a-Garrido[SUP] 1 3 [/SUP], Carolina Cubillos-Zapata[SUP] 1 4 [/SUP], ?lvaro Del Balzo-Castillo[SUP] 1 3 [/SUP], Luis A Aguirre[SUP] 1 2 [/SUP], Eduardo L?pez-Collazo[SUP] 1 2 4 [/SUP]
Affiliations
Abstract
Increased cytokine levels, acute phase reactants and immune checkpoint expression changes have been described in patients with Coronavirus Disease 2019 (COVID-19). Here, we have reported a monocyte polarization towards a low HLA-DR and high PD-L1 expression after long exposure to proteins from SARS-CoV-2. Moreover, CD86 expression was also reduced over SARS-CoV-2 proteins exposure. Additionally, T-cells proliferation was significantly reduced after stimulation with these proteins. Eventually, patients with long-term SARS-CoV-2 infection also exhibited a significant blockade of T-cells proliferation.
Keywords: COVID19; Immune checkpoints; Immunology; Infectious disease; Inflammation; PD-L1/PD-1; Pathology; Sepsis; T cell exhaustion; T cell proliferation; Virology.
. 2020 Dec;6(12):e05635.
doi: 10.1016/j.heliyon.2020.e05635. Epub 2020 Nov 30.
Proteins from SARS-CoV-2 reduce T cell proliferation: A mirror image of sepsis
Jos? Avenda?o-Ortiz[SUP] 1 2 [/SUP], Roberto Lozano-Rodr?guez[SUP] 1 2 [/SUP], Alejandro Mart?n-Quir?s[SUP] 3 [/SUP], Charbel Maroun-Eid[SUP] 1 [/SUP], Ver?nica Terr?n[SUP] 1 2 [/SUP], Jaime Valent?n[SUP] 1 2 [/SUP], Karla Montalb?n-Hern?ndez[SUP] 1 2 [/SUP], F?tima Ruiz de la Bastida[SUP] 1 2 [/SUP], Miguel A Garc?a-Garrido[SUP] 1 3 [/SUP], Carolina Cubillos-Zapata[SUP] 1 4 [/SUP], ?lvaro Del Balzo-Castillo[SUP] 1 3 [/SUP], Luis A Aguirre[SUP] 1 2 [/SUP], Eduardo L?pez-Collazo[SUP] 1 2 4 [/SUP]
Affiliations
- PMID: 33283062
- PMCID: PMC7703472
- DOI: 10.1016/j.heliyon.2020.e05635
Abstract
Increased cytokine levels, acute phase reactants and immune checkpoint expression changes have been described in patients with Coronavirus Disease 2019 (COVID-19). Here, we have reported a monocyte polarization towards a low HLA-DR and high PD-L1 expression after long exposure to proteins from SARS-CoV-2. Moreover, CD86 expression was also reduced over SARS-CoV-2 proteins exposure. Additionally, T-cells proliferation was significantly reduced after stimulation with these proteins. Eventually, patients with long-term SARS-CoV-2 infection also exhibited a significant blockade of T-cells proliferation.
Keywords: COVID19; Immune checkpoints; Immunology; Infectious disease; Inflammation; PD-L1/PD-1; Pathology; Sepsis; T cell exhaustion; T cell proliferation; Virology.