tetano
Editor, Senior Moderator
Heliyon
. 2021 Oct;7(10):e08229.
doi: 10.1016/j.heliyon.2021.e08229. Epub 2021 Oct 20.
SARS-CoV-2 and dengue virus coinfection in an adult with beta-thalassemia (trait): A case report from Bangladesh with literature review
Md Rezaul Hossain[SUP] 1 [/SUP], Monira Sarmin[SUP] 1 [/SUP], Hafizur Rahman[SUP] 2 [/SUP], Lubaba Shahrin[SUP] 1 [/SUP], Zannatun Nyma[SUP] 1 [/SUP], Tahmeed Ahmed[SUP] 1 [/SUP], Mohammod Jobayer Chisti[SUP] 1 [/SUP]
Affiliations
Abstract
Introduction: Coinfections are common in pandemics, however not in recorded patients with hemoglobinopathies. The Coronavirus Disease 2019 (COVID-19) pandemic struck Bangladesh at the beginning of March 2020, which is also an apt period for endemic Dengue fever in this monsoon region.
Case report: We report a 30-year-old man with hemoglobinopathies coinfected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Dengue virus. Dengue virus was detected by Enzyme-linked Immunosorbent Assay (ELISA). COVID-19 was confirmed by Reverse-transcription Polymerase Chain Reaction (RT-PCR) and Hemoglobin Electrophoresis revealed heterozygous beta-thalassemia or thalassemia trait. The patient was treated successfully at Dhaka Hospital in icddr,b during COVID-19 emergency response with symptomatic supportive treatment for COVID-19 and appropriate fluid therapy for dengue fever in response to daily hematocrit level. The patient's repeated RT-PCR for COVID-19 on day-21 became negative. For thalassemia, the patient was advised to have genetic counseling and family screening on discharge.
Conclusion: The possibility of coinfection between COVID-19 and Dengue fever may be considered in a COVID-19 patient with unremitting fever especially in an area where Dengue fever is epidemic that may further help to attain appropriate management of the patient.
Keywords: Bangladesh; Beta-thalassemia; COVID-19; Dengue; Hemoglobinopathies; SARS-CoV-2.
. 2021 Oct;7(10):e08229.
doi: 10.1016/j.heliyon.2021.e08229. Epub 2021 Oct 20.
SARS-CoV-2 and dengue virus coinfection in an adult with beta-thalassemia (trait): A case report from Bangladesh with literature review
Md Rezaul Hossain[SUP] 1 [/SUP], Monira Sarmin[SUP] 1 [/SUP], Hafizur Rahman[SUP] 2 [/SUP], Lubaba Shahrin[SUP] 1 [/SUP], Zannatun Nyma[SUP] 1 [/SUP], Tahmeed Ahmed[SUP] 1 [/SUP], Mohammod Jobayer Chisti[SUP] 1 [/SUP]
Affiliations
- PMID: 34693067
- PMCID: PMC8526441
- DOI: 10.1016/j.heliyon.2021.e08229
Abstract
Introduction: Coinfections are common in pandemics, however not in recorded patients with hemoglobinopathies. The Coronavirus Disease 2019 (COVID-19) pandemic struck Bangladesh at the beginning of March 2020, which is also an apt period for endemic Dengue fever in this monsoon region.
Case report: We report a 30-year-old man with hemoglobinopathies coinfected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Dengue virus. Dengue virus was detected by Enzyme-linked Immunosorbent Assay (ELISA). COVID-19 was confirmed by Reverse-transcription Polymerase Chain Reaction (RT-PCR) and Hemoglobin Electrophoresis revealed heterozygous beta-thalassemia or thalassemia trait. The patient was treated successfully at Dhaka Hospital in icddr,b during COVID-19 emergency response with symptomatic supportive treatment for COVID-19 and appropriate fluid therapy for dengue fever in response to daily hematocrit level. The patient's repeated RT-PCR for COVID-19 on day-21 became negative. For thalassemia, the patient was advised to have genetic counseling and family screening on discharge.
Conclusion: The possibility of coinfection between COVID-19 and Dengue fever may be considered in a COVID-19 patient with unremitting fever especially in an area where Dengue fever is epidemic that may further help to attain appropriate management of the patient.
Keywords: Bangladesh; Beta-thalassemia; COVID-19; Dengue; Hemoglobinopathies; SARS-CoV-2.