tetano
Editor, Senior Moderator
Open Forum Infect Dis. 2015 May 14;2(2)
fv067. doi: 10.1093/ofid/ofv067. eCollection 2015.
[h=1]Hemagglutination Inhibition Antibody Titers as a Correlate of Protection Against Seasonal A/H3N2 Influenza Disease.[/h] Benoit A[SUP]1[/SUP], Beran J[SUP]2[/SUP], Devaster JM[SUP]3[/SUP], Esen M[SUP]4[/SUP], Launay O[SUP]5[/SUP], Leroux-Roels G[SUP]6[/SUP], McElhaney JE[SUP]7[/SUP], Oostvogels L[SUP]3[/SUP], van Essen GA[SUP]8[/SUP], Gaglani M[SUP]9[/SUP], Jackson LA[SUP]10[/SUP], Vesikari T[SUP]11[/SUP], Legrand C[SUP]1[/SUP], Tibaldi F[SUP]3[/SUP], Innis BL[SUP]12[/SUP], Dew? W[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Background. To investigate the relationship between hemagglutinin-inhibition (HI) antibody levels to the risk of influenza disease, we conducted a correlate of protection analysis using pooled data from previously published randomized trials. Methods. Data on the occurrence of laboratory-confirmed influenza and HI levels pre- and postvaccination were analyzed from 4 datasets: 3 datasets included subjects aged <65 years who received inactivated trivalent influenza vaccine (TIV) or placebo, and 1 dataset included subjects aged ≥65 years who received AS03-adjuvanted TIV (AS03-TIV) or TIV. A logistic model was used to evaluate the relationship between the postvaccination titer of A/H3N2 HI antibodies and occurrence of A/H3N2 disease. We then built a receiver-operating characteristic curve to identify a potential cutoff titer between protection and no protection. Results. The baseline odds ratio of A/H3N2 disease was higher for subjects aged ≥65 years than <65 years and higher in seasons of strong epidemic intensity than moderate or low intensity. Including age and epidemic intensity as covariates, a 4-fold increase in titer was associated with a 2-fold decrease in the risk of A/H3N2 disease. Conclusions. The modeling exercise confirmed a relationship between A/H3N2 disease and HI responses, but it did not allow an evaluation of the predictive power of the HI response.
[h=4]KEYWORDS:[/h] A/H3N2; influenza; modeling; serologic correlates; vaccine
PMID: 26180823 [PubMed]
fv067. doi: 10.1093/ofid/ofv067. eCollection 2015.[h=1]Hemagglutination Inhibition Antibody Titers as a Correlate of Protection Against Seasonal A/H3N2 Influenza Disease.[/h] Benoit A[SUP]1[/SUP], Beran J[SUP]2[/SUP], Devaster JM[SUP]3[/SUP], Esen M[SUP]4[/SUP], Launay O[SUP]5[/SUP], Leroux-Roels G[SUP]6[/SUP], McElhaney JE[SUP]7[/SUP], Oostvogels L[SUP]3[/SUP], van Essen GA[SUP]8[/SUP], Gaglani M[SUP]9[/SUP], Jackson LA[SUP]10[/SUP], Vesikari T[SUP]11[/SUP], Legrand C[SUP]1[/SUP], Tibaldi F[SUP]3[/SUP], Innis BL[SUP]12[/SUP], Dew? W[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Background. To investigate the relationship between hemagglutinin-inhibition (HI) antibody levels to the risk of influenza disease, we conducted a correlate of protection analysis using pooled data from previously published randomized trials. Methods. Data on the occurrence of laboratory-confirmed influenza and HI levels pre- and postvaccination were analyzed from 4 datasets: 3 datasets included subjects aged <65 years who received inactivated trivalent influenza vaccine (TIV) or placebo, and 1 dataset included subjects aged ≥65 years who received AS03-adjuvanted TIV (AS03-TIV) or TIV. A logistic model was used to evaluate the relationship between the postvaccination titer of A/H3N2 HI antibodies and occurrence of A/H3N2 disease. We then built a receiver-operating characteristic curve to identify a potential cutoff titer between protection and no protection. Results. The baseline odds ratio of A/H3N2 disease was higher for subjects aged ≥65 years than <65 years and higher in seasons of strong epidemic intensity than moderate or low intensity. Including age and epidemic intensity as covariates, a 4-fold increase in titer was associated with a 2-fold decrease in the risk of A/H3N2 disease. Conclusions. The modeling exercise confirmed a relationship between A/H3N2 disease and HI responses, but it did not allow an evaluation of the predictive power of the HI response.
[h=4]KEYWORDS:[/h] A/H3N2; influenza; modeling; serologic correlates; vaccine
PMID: 26180823 [PubMed]