tetano
Editor, Senior Moderator
Virol J. 2012 Jun 6;9(1):104. [Epub ahead of print]
Heterogeneous virulence of pandemic 2009 influenza H1N1 virus in mice.
Farooqui A, Leon AJ, Lei Y, Wang P, Huang J, Tenorio R, Dong W, Rubino S, Lin J, Li G, Zhao Z, Kelvin DJ.
Abstract
ABSTRACT:
BACKGROUND:
Understanding the pathogenesis of influenza infection is a key factor leading to theprevention and control of future outbreaks. Pandemic 2009 Influenza H1N1 infection,although frequently mild, led to a severe and fatal form of disease in certain cases that makeits virulence nature debatable. Much effort has been made toward explaining the determinantsof disease severity; however, no absolute reason has been established.
RESULTS:
This study presents the heterogeneous virulence of clinically similar strains of pandemic 2009influenza virus in human alveolar adenocarcinoma cells and mice. The viruses were obtainedfrom patients who were admitted in a local hospital in China with a similar course ofinfection and recovered. The A/Nanchang/8002/2009 and A/Nanchang/8011/2009 virusesshowed efficient replication and high lethality in mice while infection withA/Nanchang/8008/2009 was not lethal with impaired viral replication, minimal pathologyand modest proinflammatory activity in lungs. Sequence analysis displayed prominentdifferences between polymerase subunits (PB2 and PA) of viral genomes that might correlatewith their different phenotypic behavior.
CONCLUSIONS:
The study confirms that biological heterogeneity, linked with the extent of viral replication,exists among pandemic H1N1 strains that may serve as a benchmark for future investigationson influenza pathogenesis.
PMID:
22672588
[PubMed - as supplied by publisher]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/22672588
Heterogeneous virulence of pandemic 2009 influenza H1N1 virus in mice.
Farooqui A, Leon AJ, Lei Y, Wang P, Huang J, Tenorio R, Dong W, Rubino S, Lin J, Li G, Zhao Z, Kelvin DJ.
Abstract
ABSTRACT:
BACKGROUND:
Understanding the pathogenesis of influenza infection is a key factor leading to theprevention and control of future outbreaks. Pandemic 2009 Influenza H1N1 infection,although frequently mild, led to a severe and fatal form of disease in certain cases that makeits virulence nature debatable. Much effort has been made toward explaining the determinantsof disease severity; however, no absolute reason has been established.
RESULTS:
This study presents the heterogeneous virulence of clinically similar strains of pandemic 2009influenza virus in human alveolar adenocarcinoma cells and mice. The viruses were obtainedfrom patients who were admitted in a local hospital in China with a similar course ofinfection and recovered. The A/Nanchang/8002/2009 and A/Nanchang/8011/2009 virusesshowed efficient replication and high lethality in mice while infection withA/Nanchang/8008/2009 was not lethal with impaired viral replication, minimal pathologyand modest proinflammatory activity in lungs. Sequence analysis displayed prominentdifferences between polymerase subunits (PB2 and PA) of viral genomes that might correlatewith their different phenotypic behavior.
CONCLUSIONS:
The study confirms that biological heterogeneity, linked with the extent of viral replication,exists among pandemic H1N1 strains that may serve as a benchmark for future investigationson influenza pathogenesis.
PMID:
22672588
[PubMed - as supplied by publisher]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/22672588