tetano
Editor, Senior Moderator
MBio. 2018 Aug 7;9(4). pii: e01408-18. doi: 10.1128/mBio.01408-18.
[h=1]Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses.[/h] Zhao M[SUP]#[/SUP][SUP]1,[/SUP][SUP]2[/SUP], Liu K[SUP]#[/SUP][SUP]3,[/SUP][SUP]4[/SUP], Luo J[SUP]#[/SUP][SUP]5,[/SUP][SUP]6,[/SUP][SUP]7[/SUP], Tan S[SUP]1[/SUP], Quan C[SUP]4[/SUP], Zhang S[SUP]1[/SUP], Chai Y[SUP]1[/SUP], Qi J[SUP]1[/SUP], Li Y[SUP]1[/SUP], Bi Y[SUP]1,[/SUP][SUP]8,[/SUP][SUP]9[/SUP], Xiao H[SUP]10[/SUP], Wong G[SUP]1,[/SUP][SUP]8,[/SUP][SUP]9[/SUP], Zhou J[SUP]4[/SUP], Jiang T[SUP]5,[/SUP][SUP]6,[/SUP][SUP]7[/SUP], Liu W[SUP]1[/SUP], Yu H[SUP]11[/SUP], Yan J[SUP]1[/SUP], Liu Y[SUP]9[/SUP], Shu Y[SUP]4[/SUP], Wu G[SUP]4[/SUP], Wu A[SUP]12,[/SUP][SUP]6[/SUP], Gao GF[SUP]13,[/SUP][SUP]2,[/SUP][SUP]3,[/SUP][SUP]4,[/SUP][SUP]8,[/SUP][SUP]9[/SUP], Liu WJ[SUP]14,[/SUP][SUP]4,[/SUP][SUP]9[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Against a backdrop of seasonal influenza virus epidemics, emerging avian influenza viruses (AIVs) occasionally jump from birds to humans, posing a public health risk, especially with the recent sharp increase in H7N9 infections. Evaluations of cross-reactive T-cell immunity to seasonal influenza viruses and human-infecting AIVs have been reported previously. However, the roles of influenza A virus-derived epitopes in the cross-reactive T-cell responses and heterosubtypic protections are not well understood; understanding those roles is important for preventing and controlling new emerging AIVs. Here, among the members of a healthy population presumed to have previously been infected by pandemic H1N1 (pH1N1), we found that pH1N1-specific T cells showed cross- but biased reactivity to human-infecting AIVs, i.e., H5N1, H6N1, H7N9, and H9N2, which correlates with distinct protections. Through a T-cell epitope-based phylogenetic analysis, the cellular immunogenic clustering expanded the relevant conclusions to a broader range of virus strains. We defined the potential key conserved epitopes required for cross-protection and revealed the molecular basis for the immunogenic variations. Our study elucidated an overall profile of cross-reactivity to AIVs and provided useful recommendations for broad-spectrum vaccine development.IMPORTANCE We revealed preexisting but biased T-cell reactivity of pH1N1 influenza virus to human-infecting AIVs, which provided distinct protections. The cross-reactive T-cell recognition had a regular pattern that depended on the T-cell epitope matrix revealed via bioinformatics analysis. Our study elucidated an overall profile of cross-reactivity to AIVs and provided useful recommendations for broad-spectrum vaccine development.
[h=4]KEYWORDS:[/h] T-cell responses; avian influenza viruses; cross-reactivity; heterosubtypic protection
PMID: 30087171 DOI: 10.1128/mBio.01408-18
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[h=1]Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses.[/h] Zhao M[SUP]#[/SUP][SUP]1,[/SUP][SUP]2[/SUP], Liu K[SUP]#[/SUP][SUP]3,[/SUP][SUP]4[/SUP], Luo J[SUP]#[/SUP][SUP]5,[/SUP][SUP]6,[/SUP][SUP]7[/SUP], Tan S[SUP]1[/SUP], Quan C[SUP]4[/SUP], Zhang S[SUP]1[/SUP], Chai Y[SUP]1[/SUP], Qi J[SUP]1[/SUP], Li Y[SUP]1[/SUP], Bi Y[SUP]1,[/SUP][SUP]8,[/SUP][SUP]9[/SUP], Xiao H[SUP]10[/SUP], Wong G[SUP]1,[/SUP][SUP]8,[/SUP][SUP]9[/SUP], Zhou J[SUP]4[/SUP], Jiang T[SUP]5,[/SUP][SUP]6,[/SUP][SUP]7[/SUP], Liu W[SUP]1[/SUP], Yu H[SUP]11[/SUP], Yan J[SUP]1[/SUP], Liu Y[SUP]9[/SUP], Shu Y[SUP]4[/SUP], Wu G[SUP]4[/SUP], Wu A[SUP]12,[/SUP][SUP]6[/SUP], Gao GF[SUP]13,[/SUP][SUP]2,[/SUP][SUP]3,[/SUP][SUP]4,[/SUP][SUP]8,[/SUP][SUP]9[/SUP], Liu WJ[SUP]14,[/SUP][SUP]4,[/SUP][SUP]9[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Against a backdrop of seasonal influenza virus epidemics, emerging avian influenza viruses (AIVs) occasionally jump from birds to humans, posing a public health risk, especially with the recent sharp increase in H7N9 infections. Evaluations of cross-reactive T-cell immunity to seasonal influenza viruses and human-infecting AIVs have been reported previously. However, the roles of influenza A virus-derived epitopes in the cross-reactive T-cell responses and heterosubtypic protections are not well understood; understanding those roles is important for preventing and controlling new emerging AIVs. Here, among the members of a healthy population presumed to have previously been infected by pandemic H1N1 (pH1N1), we found that pH1N1-specific T cells showed cross- but biased reactivity to human-infecting AIVs, i.e., H5N1, H6N1, H7N9, and H9N2, which correlates with distinct protections. Through a T-cell epitope-based phylogenetic analysis, the cellular immunogenic clustering expanded the relevant conclusions to a broader range of virus strains. We defined the potential key conserved epitopes required for cross-protection and revealed the molecular basis for the immunogenic variations. Our study elucidated an overall profile of cross-reactivity to AIVs and provided useful recommendations for broad-spectrum vaccine development.IMPORTANCE We revealed preexisting but biased T-cell reactivity of pH1N1 influenza virus to human-infecting AIVs, which provided distinct protections. The cross-reactive T-cell recognition had a regular pattern that depended on the T-cell epitope matrix revealed via bioinformatics analysis. Our study elucidated an overall profile of cross-reactivity to AIVs and provided useful recommendations for broad-spectrum vaccine development.
[h=4]KEYWORDS:[/h] T-cell responses; avian influenza viruses; cross-reactivity; heterosubtypic protection
PMID: 30087171 DOI: 10.1128/mBio.01408-18
Free full text