Highly Pathogenic Reassortant Avian Influenza A(H5N1) Virus Clade 2.3.2.1a in Poultry, Bhutan

[tetano]

Emerg Infect Dis. 2016 Dec 15;22(12). doi: 10.3201/eid2212.160611. [Epub ahead of print]
[h=1]Highly Pathogenic Reassortant Avian Influenza A(H5N1) Virus Clade 2.3.2.1a in Poultry, Bhutan.[/h] Marinova-Petkova A, Franks J, Tenzin S, Dahal N, Dukpa K, Dorjee J, Feeroz MM, Rehg JE, Barman S, Krauss S, McKenzie P, Webby RJ, Webster RG.
[h=3]Abstract[/h] Highly pathogenic avian influenza A(H5N1), clade 2.3.2.1a, with an H9-like polymerase basic protein 1 gene, isolated in Bhutan in 2012, replicated faster in vitro than its H5N1 parental genotype and was transmitted more efficiently in a chicken model than in a ferret model. These properties likely help limit/eradicate outbreaks, combined with strict control measures.


[h=4]KEYWORDS:[/h] Bhutan; Indian subcontinent; avian influenza; clade 2.3.2.1a; ferret model: respiratory diseases; highly pathogenic avian influenza H5N1; influenza; influenza virus; outbreak; reassortant; transmission; viruses; zoonoses

PMID: 27584733 DOI: 10.3201/eid2212.160611
[PubMed - as supplied by publisher] Free full text