tetano
Editor, Senior Moderator
Hum Immunol
. 2021 Jan 20;S0198-8859(21)00015-X.
doi: 10.1016/j.humimm.2021.01.008. Online ahead of print.
Predictive immunogenetic markers in COVID-19
Mauro de Meira Leite[SUP] 1 [/SUP], Faviel F Gonzalez-Galarza[SUP] 2 [/SUP], Bruno Conde Costa da Silva[SUP] 3 [/SUP], Derek Middleton[SUP] 4 [/SUP], Eduardo Jos? Melo Dos Santos[SUP] 3 [/SUP]
Affiliations
Abstract
Immunorelevant genes are among the most probable modulators of coronavirus disease 2019 (COVID-19) progression and prognosis. However, in the few months of the pandemic, data generated on host genetics has been scarce. The present study retrieved data sets of HLA-B alleles, KIR genes and functional single nucleotide polymorphisms (SNPs) in cytokines related to COVID-19 cytokine storm from two publicly available databases: Allele Frequency Net Database and Ensembl, and correlated these frequency data with Case Fatality Rate (CFR) and Daily Death Rates (DDR) across countries. Correlations of eight HLA-B alleles and polymorphisms in three cytokine genes (IL6, IL10, and IL12B) were observed and were mainly associated with DDR. Additionally, HLA-B correlations suggest that differences in allele affinities to SARS-CoV-2 peptides are also associated with DDR. These results may provide rationale for future host genetic marker surveys on COVID-19.
Keywords: COVID-19; Cytokine polymorphisms; HLA-B; KIR.
. 2021 Jan 20;S0198-8859(21)00015-X.
doi: 10.1016/j.humimm.2021.01.008. Online ahead of print.
Predictive immunogenetic markers in COVID-19
Mauro de Meira Leite[SUP] 1 [/SUP], Faviel F Gonzalez-Galarza[SUP] 2 [/SUP], Bruno Conde Costa da Silva[SUP] 3 [/SUP], Derek Middleton[SUP] 4 [/SUP], Eduardo Jos? Melo Dos Santos[SUP] 3 [/SUP]
Affiliations
- PMID: 33546902
- DOI: 10.1016/j.humimm.2021.01.008
Abstract
Immunorelevant genes are among the most probable modulators of coronavirus disease 2019 (COVID-19) progression and prognosis. However, in the few months of the pandemic, data generated on host genetics has been scarce. The present study retrieved data sets of HLA-B alleles, KIR genes and functional single nucleotide polymorphisms (SNPs) in cytokines related to COVID-19 cytokine storm from two publicly available databases: Allele Frequency Net Database and Ensembl, and correlated these frequency data with Case Fatality Rate (CFR) and Daily Death Rates (DDR) across countries. Correlations of eight HLA-B alleles and polymorphisms in three cytokine genes (IL6, IL10, and IL12B) were observed and were mainly associated with DDR. Additionally, HLA-B correlations suggest that differences in allele affinities to SARS-CoV-2 peptides are also associated with DDR. These results may provide rationale for future host genetic marker surveys on COVID-19.
Keywords: COVID-19; Cytokine polymorphisms; HLA-B; KIR.