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Hum Vaccin Immunother . Pre-graft vaccination or infection do not decrease COVID-19 infections in recipients of allogeneic stem cell transplantatio

tetano

Editor, Senior Moderator
Hum Vaccin Immunother


. 2024 Dec 31;20(1):2370970.
doi: 10.1080/21645515.2024.2370970. Epub 2024 Jul 8. Pre-graft vaccination or infection do not decrease COVID-19 infections in recipients of allogeneic stem cell transplantation vaccinated and/or protected by immunotherapy after transplant

Valentin Letailleur[SUP] 1 [/SUP], Amandine Le Bourgeois[SUP] 1 [/SUP], Thierry Guillaume[SUP] 1 2 [/SUP], Alice Garnier[SUP] 1 [/SUP], Pierre Peterlin[SUP] 1 [/SUP], Maxime Jullien[SUP] 1 [/SUP], Chloe Antier[SUP] 1 [/SUP], Marie-Christine Béné[SUP] 3 [/SUP], Patrice Chevallier[SUP] 1 2 [/SUP]



Affiliations
Abstract

The impact of pre-graft COVID-19 vaccinations in donor or recipient as well as pre-graft infection has been studied in 157 adults having received allogeneic stem cell transplantation (Allo-SCT) for various hematological diseases during the delta/omicron waves. We showed here that pre-Allo-SCT COVID-19 vaccination and/or infection do not provide more protection in patients receiving vaccine, immunotherapy or both after transplant. COVID-19 vaccination is and remains of crucial importance after Allo-SCT, reinforcing the recommendation to start COVID-19 vaccination as soon as the third month following the transplant.

Keywords: BNT162b2; COVID-19; allogeneic; infection; mRNA-1273; vaccine.

 
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