tetano
Editor, Senior Moderator
Hum Vaccin Immunother
. 2021 Nov 29;1-14.
doi: 10.1080/21645515.2021.1985891. Online ahead of print.
Vaccinal antibodies: Fc antibody engineering to improve the antiviral antibody response and induce vaccine-like effects
Dhuha H Nawab[SUP] 1 [/SUP]
Affiliations
Abstract
The coronavirus disease 2019 (COVID-19) pandemic highlights the urgent clinical need for efficient virus therapies and vaccines. Although the functional importance of antibodies is indisputable in viral infections, there are still significant unmet needs that require vast improvements in antibody-based therapeutics. The IgG Fc domain can be engineered to produce antibodies with tailored and potent responses that will meet these clinical demands. Engaging Fc receptors (FcRs) to perform effector functions as cytotoxicity, phagocytosis, complement activation, intracellular neutralization and controlling antibody persistence. Furthermore, it produces vaccine-like effects by activating signals to stimulate T-cell responses, have proven to be required for protection, as neutralization alone does not off the full protection capacity of antibodies. This review highlights antiviral Fc functions and FcRs' contributions in linking innate and adaptive immunity against viral threats. Moreover, it provides the latest Fc engineering strategies to improve the safety and efficacy of human antiviral antibodies and vaccines.
Keywords: Antibody engineering; Fc effector functions; T-cell responses; antibody antiviral responses; antibody intracellular neutralization; antibody recycling; vaccines.
. 2021 Nov 29;1-14.
doi: 10.1080/21645515.2021.1985891. Online ahead of print.
Vaccinal antibodies: Fc antibody engineering to improve the antiviral antibody response and induce vaccine-like effects
Dhuha H Nawab[SUP] 1 [/SUP]
Affiliations
- PMID: 34844516
- DOI: 10.1080/21645515.2021.1985891
Abstract
The coronavirus disease 2019 (COVID-19) pandemic highlights the urgent clinical need for efficient virus therapies and vaccines. Although the functional importance of antibodies is indisputable in viral infections, there are still significant unmet needs that require vast improvements in antibody-based therapeutics. The IgG Fc domain can be engineered to produce antibodies with tailored and potent responses that will meet these clinical demands. Engaging Fc receptors (FcRs) to perform effector functions as cytotoxicity, phagocytosis, complement activation, intracellular neutralization and controlling antibody persistence. Furthermore, it produces vaccine-like effects by activating signals to stimulate T-cell responses, have proven to be required for protection, as neutralization alone does not off the full protection capacity of antibodies. This review highlights antiviral Fc functions and FcRs' contributions in linking innate and adaptive immunity against viral threats. Moreover, it provides the latest Fc engineering strategies to improve the safety and efficacy of human antiviral antibodies and vaccines.
Keywords: Antibody engineering; Fc effector functions; T-cell responses; antibody antiviral responses; antibody intracellular neutralization; antibody recycling; vaccines.