tetano
Editor, Senior Moderator
Sci China Life Sci. 2017 Nov 29. doi: 10.1007/s11427-017-9241-3. [Epub ahead of print]
[h=1]Human T-cell immunity against the emerging and re-emerging viruses.[/h] Zhao M[SUP]1[/SUP], Zhang H[SUP]2[/SUP], Liu K[SUP]2[/SUP], Gao GF[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Liu WJ[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Over the past decade, we have seen an alarming number of high-profile outbreaks of newly emerging and re-emerging viruses. Recent outbreaks of avian influenza viruses, Middle East respiratory syndrome coronaviruses, Zika virus and Ebola virus present great threats to global health. Considering the pivotal role of host T-cell immunity in the alleviation of symptoms and the clearance of viruses in patients, there are three issues to be primarily concerned about T-cell immunity when a new virus emerges: first, does the population possess pre-existing T-cells against the new virus through previous infections of genetically relevant viruses; second, does a proper immune response arise in the patients to provide protection through an immunopathogenic effect; lastly, how long can the virus-specific immune memory persist. Herein, we summarize the current updates on the characteristics of human T-cell immunological responses against recently emerged or re-emerged viruses, and emphasize the necessity for timely investigation on the T-cell features of these viral diseases, which may provide beneficial recommendations for clinical diagnosis and vaccine development.
[h=4]KEYWORDS:[/h] Ebola; H7N9; MERS-CoV; T-cell; Zika; avian influenza; cross-reactivity; emerging viruses; human immunity
PMID: 29294219 DOI: 10.1007/s11427-017-9241-3
[h=1]Human T-cell immunity against the emerging and re-emerging viruses.[/h] Zhao M[SUP]1[/SUP], Zhang H[SUP]2[/SUP], Liu K[SUP]2[/SUP], Gao GF[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Liu WJ[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Over the past decade, we have seen an alarming number of high-profile outbreaks of newly emerging and re-emerging viruses. Recent outbreaks of avian influenza viruses, Middle East respiratory syndrome coronaviruses, Zika virus and Ebola virus present great threats to global health. Considering the pivotal role of host T-cell immunity in the alleviation of symptoms and the clearance of viruses in patients, there are three issues to be primarily concerned about T-cell immunity when a new virus emerges: first, does the population possess pre-existing T-cells against the new virus through previous infections of genetically relevant viruses; second, does a proper immune response arise in the patients to provide protection through an immunopathogenic effect; lastly, how long can the virus-specific immune memory persist. Herein, we summarize the current updates on the characteristics of human T-cell immunological responses against recently emerged or re-emerged viruses, and emphasize the necessity for timely investigation on the T-cell features of these viral diseases, which may provide beneficial recommendations for clinical diagnosis and vaccine development.
[h=4]KEYWORDS:[/h] Ebola; H7N9; MERS-CoV; T-cell; Zika; avian influenza; cross-reactivity; emerging viruses; human immunity
PMID: 29294219 DOI: 10.1007/s11427-017-9241-3