tetano
Editor, Senior Moderator
Am J Transplant. 2019 Feb 12. doi: 10.1111/ajt.15296. [Epub ahead of print]
[h=1]Humoral Response to Natural Influenza Infection in Solid Organ Transplant Recipients.[/h] Hirzel C[SUP]1[/SUP], Ferreira VH[SUP]1[/SUP], L'Huillier A[SUP]1[/SUP], Hoschler K[SUP]2[/SUP], Cordero E[SUP]3[/SUP], Limaye AP[SUP]4[/SUP], Englund JA[SUP]5[/SUP], Reid G[SUP]6[/SUP], Humar A[SUP]1[/SUP], Kumar D[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The humoral immune response of transplant recipients to influenza vaccination has been studied in detail. In contrast, the hemagglutinin inhibiting (HI) antibody response evoked by natural influenza infection and its impact on viral kinetics is unknown. In this prospective multicenter cohort study of natural influenza infection in transplant recipients, we measured HI antibody titers at presentation and four weeks later. Serial nasopharyngeal viral loads were determined using quantitative influenza A PCR. We analyzed 196 transplant recipients with influenza infection. In the cohort of organ transplant patients with influenza A (n=116), seropositivity rates for strain-specific antibodies were 44.0% (95%CI 31.5-53.2%) at diagnosis and 64.7% (95%CI 55.4-72.9%) four weeks post-infection. Seroconversion was observed in 32.8% (95%CI 24.7-41.9%) of cases. Lung transplant recipients were more likely to seroconvert (p=0.002) and vaccine recipients were less likely to seroconvert (p=0.024). A subset of patients (n=30) who were unresponsive to prior vaccination were also unresponsive to natural infection. There was no correlation between viral kinetics and the antibody response. This study provides novel data on the seroresponse to influenza infection in transplant patients and its relationship to a number of parameters including prior vaccination status, virologic measures, and clinical variables. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
PMID: 30748090 DOI: 10.1111/ajt.15296
[h=1]Humoral Response to Natural Influenza Infection in Solid Organ Transplant Recipients.[/h] Hirzel C[SUP]1[/SUP], Ferreira VH[SUP]1[/SUP], L'Huillier A[SUP]1[/SUP], Hoschler K[SUP]2[/SUP], Cordero E[SUP]3[/SUP], Limaye AP[SUP]4[/SUP], Englund JA[SUP]5[/SUP], Reid G[SUP]6[/SUP], Humar A[SUP]1[/SUP], Kumar D[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The humoral immune response of transplant recipients to influenza vaccination has been studied in detail. In contrast, the hemagglutinin inhibiting (HI) antibody response evoked by natural influenza infection and its impact on viral kinetics is unknown. In this prospective multicenter cohort study of natural influenza infection in transplant recipients, we measured HI antibody titers at presentation and four weeks later. Serial nasopharyngeal viral loads were determined using quantitative influenza A PCR. We analyzed 196 transplant recipients with influenza infection. In the cohort of organ transplant patients with influenza A (n=116), seropositivity rates for strain-specific antibodies were 44.0% (95%CI 31.5-53.2%) at diagnosis and 64.7% (95%CI 55.4-72.9%) four weeks post-infection. Seroconversion was observed in 32.8% (95%CI 24.7-41.9%) of cases. Lung transplant recipients were more likely to seroconvert (p=0.002) and vaccine recipients were less likely to seroconvert (p=0.024). A subset of patients (n=30) who were unresponsive to prior vaccination were also unresponsive to natural infection. There was no correlation between viral kinetics and the antibody response. This study provides novel data on the seroresponse to influenza infection in transplant patients and its relationship to a number of parameters including prior vaccination status, virologic measures, and clinical variables. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
PMID: 30748090 DOI: 10.1111/ajt.15296