tetano
Editor, Senior Moderator
EMBO J. 2013 Feb 19. doi: 10.1038/emboj.2013.28. [Epub ahead of print]
I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection.
Mancino A, Habbeddine M, Johnson E, Luron L, Bebien M, Memet S, Fong C, Bajenoff M, Wu X, Karin M, Caamano J, Chi H, Seed M, Lawrence T.
Source
1] Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille Universit?, UM2, Marseille, France [2] Institut National de la Sant? et de la Recherche M?dicale (INSERM), U1104, Marseille, France [3] Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France.
Abstract
Dendritic cells (DC) are required for priming antigen-specific T cells and acquired immunity to many important human pathogens, including Mycobacteriuim tuberculosis (TB) and influenza. However, inappropriate priming of auto-reactive T cells is linked with autoimmune disease. Understanding the molecular mechanisms that regulate the priming and activation of na?ve T cells is critical for development of new improved vaccines and understanding the pathogenesis of autoimmune diseases. The serine/threonine kinase IKKα (CHUK) has previously been shown to have anti-inflammatory activity and inhibit innate immunity. Here, we show that IKKα is required in DC for priming antigen-specific T cells and acquired immunity to the human pathogen Listeria monocytogenes. We describe a new role for IKKα in regulation of IRF3 activity and the functional maturation of DC. This presents a unique role for IKKα in dampening inflammation while simultaneously promoting adaptive immunity that could have important implications for the development of new vaccine adjuvants and treatment of autoimmune diseases.
PMID:
23422957
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23422957
I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection.
Mancino A, Habbeddine M, Johnson E, Luron L, Bebien M, Memet S, Fong C, Bajenoff M, Wu X, Karin M, Caamano J, Chi H, Seed M, Lawrence T.
Source
1] Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille Universit?, UM2, Marseille, France [2] Institut National de la Sant? et de la Recherche M?dicale (INSERM), U1104, Marseille, France [3] Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France.
Abstract
Dendritic cells (DC) are required for priming antigen-specific T cells and acquired immunity to many important human pathogens, including Mycobacteriuim tuberculosis (TB) and influenza. However, inappropriate priming of auto-reactive T cells is linked with autoimmune disease. Understanding the molecular mechanisms that regulate the priming and activation of na?ve T cells is critical for development of new improved vaccines and understanding the pathogenesis of autoimmune diseases. The serine/threonine kinase IKKα (CHUK) has previously been shown to have anti-inflammatory activity and inhibit innate immunity. Here, we show that IKKα is required in DC for priming antigen-specific T cells and acquired immunity to the human pathogen Listeria monocytogenes. We describe a new role for IKKα in regulation of IRF3 activity and the functional maturation of DC. This presents a unique role for IKKα in dampening inflammation while simultaneously promoting adaptive immunity that could have important implications for the development of new vaccine adjuvants and treatment of autoimmune diseases.
PMID:
23422957
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23422957