tetano
Editor, Senior Moderator
IDCases
. 2021 May 28;e01172.
doi: 10.1016/j.idcr.2021.e01172. Online ahead of print.
Autoptic identification of disseminated mucormycosis in a young male presenting with cerebrovascular event, multi-organ dysfunction and COVID-19 infection
Vidya Krishna[SUP] 1 [/SUP], Jaymin Morjaria[SUP] 2 [/SUP], Rona Jalandari[SUP] 3 [/SUP], Fatima Omar[SUP] 3 [/SUP], Sundeep Kaul[SUP] 2 4 [/SUP]
Affiliations
Abstract
Among the secondary fungal infections in Coronavirus-19 (COVID-19) infection, Aspergillosis has been reported more often than Mucormycosis. Disseminated mucormycosis is almost always a disease of severely immunosuppressed hosts. We report a young obese Asian male who was admitted with an acute anterior cerebral artery (ACA) territory infarct and severe COVID-19 pneumonitis to the intensive care unit (ICU). He had a complicated stay with recurrent episodes of vasoplegic shock and multi-organ dysfunction. At autopsy, he was confirmed to have disseminated mucormycosis. We believe this to be the first documented case of disseminated mucormycosis in an immunocompetent host with COVID-19 infection. The lack of sensitive non-invasive modalities and biomarkers to diagnose mucormycosis, along with the extremely high mortality in untreated cases, present a unique challenge to clinicians dealing with critically ill patients with COVID-19.
Keywords: COVID-19; fungal; mucormycosis; secondary infections.
. 2021 May 28;e01172.
doi: 10.1016/j.idcr.2021.e01172. Online ahead of print.
Autoptic identification of disseminated mucormycosis in a young male presenting with cerebrovascular event, multi-organ dysfunction and COVID-19 infection
Vidya Krishna[SUP] 1 [/SUP], Jaymin Morjaria[SUP] 2 [/SUP], Rona Jalandari[SUP] 3 [/SUP], Fatima Omar[SUP] 3 [/SUP], Sundeep Kaul[SUP] 2 4 [/SUP]
Affiliations
- PMID: 34075329
- PMCID: PMC8161734
- DOI: 10.1016/j.idcr.2021.e01172
Abstract
Among the secondary fungal infections in Coronavirus-19 (COVID-19) infection, Aspergillosis has been reported more often than Mucormycosis. Disseminated mucormycosis is almost always a disease of severely immunosuppressed hosts. We report a young obese Asian male who was admitted with an acute anterior cerebral artery (ACA) territory infarct and severe COVID-19 pneumonitis to the intensive care unit (ICU). He had a complicated stay with recurrent episodes of vasoplegic shock and multi-organ dysfunction. At autopsy, he was confirmed to have disseminated mucormycosis. We believe this to be the first documented case of disseminated mucormycosis in an immunocompetent host with COVID-19 infection. The lack of sensitive non-invasive modalities and biomarkers to diagnose mucormycosis, along with the extremely high mortality in untreated cases, present a unique challenge to clinicians dealing with critically ill patients with COVID-19.
Keywords: COVID-19; fungal; mucormycosis; secondary infections.