tetano
Editor, Senior Moderator
Microbes Infect. 2017 Sep 23. pii: S1286-4579(17)30152-1. doi: 10.1016/j.micinf.2017.09.008. [Epub ahead of print]
[h=1]Identification of a key amino acid in hemagglutinin that increases human-type receptor binding and transmission of an H6N2 avian influenza virus.[/h] Qu Z[SUP]1[/SUP], Ma S[SUP]1[/SUP], Kong H[SUP]1[/SUP], Deng G[SUP]1[/SUP], Shi J[SUP]1[/SUP], Liu L[SUP]1[/SUP], Suzuki Y[SUP]2[/SUP], Chen H[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Binding exclusively to human-type receptors is a prerequisite for avian influenza viruses to transmit from human to human. We previously reported that 34% of H6 avian influenza viruses recognize the human-type receptor, but their affinity for the avian-type receptor remains higher than that for the human-type receptor. Here, we found that a single amino acid change from glutamine to leucine at position 226 of hemagglutinin caused a switch in receptor-binding preference from avian-type to human-type receptors and rendered A/chicken/Guangdong/S1312/2010(H6N2) capable of respiratory droplet transmission in guinea pigs.
Copyright ? 2017. Published by Elsevier Masson SAS.
[h=4]KEYWORDS:[/h] H6 subtype avian influenza viruses; guinea pigs; receptor-binding; respiratory droplet transmission
PMID: 28951329 DOI: 10.1016/j.micinf.2017.09.008
[h=1]Identification of a key amino acid in hemagglutinin that increases human-type receptor binding and transmission of an H6N2 avian influenza virus.[/h] Qu Z[SUP]1[/SUP], Ma S[SUP]1[/SUP], Kong H[SUP]1[/SUP], Deng G[SUP]1[/SUP], Shi J[SUP]1[/SUP], Liu L[SUP]1[/SUP], Suzuki Y[SUP]2[/SUP], Chen H[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Binding exclusively to human-type receptors is a prerequisite for avian influenza viruses to transmit from human to human. We previously reported that 34% of H6 avian influenza viruses recognize the human-type receptor, but their affinity for the avian-type receptor remains higher than that for the human-type receptor. Here, we found that a single amino acid change from glutamine to leucine at position 226 of hemagglutinin caused a switch in receptor-binding preference from avian-type to human-type receptors and rendered A/chicken/Guangdong/S1312/2010(H6N2) capable of respiratory droplet transmission in guinea pigs.
Copyright ? 2017. Published by Elsevier Masson SAS.
[h=4]KEYWORDS:[/h] H6 subtype avian influenza viruses; guinea pigs; receptor-binding; respiratory droplet transmission
PMID: 28951329 DOI: 10.1016/j.micinf.2017.09.008