tetano
Editor, Senior Moderator
J Infect Dis. 2013 Aug 30. [Epub ahead of print]
IFITM3 and susceptibility to respiratory viral infections in the community.
Mills TC, Rautanen A, Elliott KS, Parks T, Naranbhai V, Ieven MM, Butler CC, Little P, Verheij T, Garrard CS, Hinds C, Goossens H, Chapman S, Hill AV.
Source
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Abstract
Interferon-inducible transmembrane proteins 1, 2 and 3 (IFITM1,2 and 3) are viral restriction factors that mediate cellular resistance to several viruses. We have genotyped a possible splice-site altering SNP (rs12252) in the IFITM3 gene in 34 H1N1 influenza cases with severe pneumonia and over 5000 individuals comprising cases of community-acquired mild lower respiratory tract infection and matched controls of Caucasian ancestry. We found evidence of an association between rs12252 rare allele homozygotes and susceptibility to mild influenza (in patients attending primary care), but could not confirm a previously reported association between this SNP and susceptibility to severe H1N1 infection.
PMID:
23997235
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23997235
IFITM3 and susceptibility to respiratory viral infections in the community.
Mills TC, Rautanen A, Elliott KS, Parks T, Naranbhai V, Ieven MM, Butler CC, Little P, Verheij T, Garrard CS, Hinds C, Goossens H, Chapman S, Hill AV.
Source
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Abstract
Interferon-inducible transmembrane proteins 1, 2 and 3 (IFITM1,2 and 3) are viral restriction factors that mediate cellular resistance to several viruses. We have genotyped a possible splice-site altering SNP (rs12252) in the IFITM3 gene in 34 H1N1 influenza cases with severe pneumonia and over 5000 individuals comprising cases of community-acquired mild lower respiratory tract infection and matched controls of Caucasian ancestry. We found evidence of an association between rs12252 rare allele homozygotes and susceptibility to mild influenza (in patients attending primary care), but could not confirm a previously reported association between this SNP and susceptibility to severe H1N1 infection.
PMID:
23997235
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23997235