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IgE cross-linking impairs monocyte antiviral responses and inhibits influenza-driven Th1 differentiation

tetano

Editor, Senior Moderator
J Allergy Clin Immunol. 2017 Jan 10. pii: S0091-6749(17)30004-0. doi: 10.1016/j.jaci.2016.11.035. [Epub ahead of print]
[h=1]IgE cross-linking impairs monocyte antiviral responses and inhibits influenza-driven Th1 differentiation.[/h] Rowe RK[SUP]1[/SUP], Pyle DM[SUP]2[/SUP], Tomlinson AR[SUP]3[/SUP], Lv T[SUP]1[/SUP], Hu Z[SUP]1[/SUP], Gill MA[SUP]4[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] [h=4]CAPSULE SUMMARY:[/h] IgE-mediated allergic activation impairs the virus-induced Th1 lymphocyte priming capacity of human monocytes in response to influenza exposure. These findings represent one potential mechanism contributing to the link between viral infections and allergic disease.
Copyright ? 2017. Published by Elsevier Inc.


[h=4]KEYWORDS:[/h] IgE; IgE cross-linking; T cell differentiation; Th1; co-stimulation; influenza; monocytes

PMID: 28087327 DOI: 10.1016/j.jaci.2016.11.035
[PubMed - as supplied by publisher]
 
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