tetano
Editor, Senior Moderator
Clin Infect Dis. 2015 Nov 12. pii: civ952. [Epub ahead of print]
[h=1]Illness Severity and Work Productivity Loss among Working Adults with Medically-Attended Acute Respiratory Illnesses: US Influenza Vaccine Effectiveness Network 2012-2013.[/h] Petrie JG[SUP]1[/SUP], Cheng C[SUP]1[/SUP], Malosh RE[SUP]1[/SUP], VanWormer JJ[SUP]2[/SUP], Flannery B[SUP]3[/SUP], Zimmerman RK[SUP]4[/SUP], Gaglani M[SUP]5[/SUP], Jackson ML[SUP]6[/SUP], King JP[SUP]2[/SUP], Nowalk MP[SUP]4[/SUP], Benoit J[SUP]6[/SUP], Robertson A[SUP]5[/SUP], Thaker SN[SUP]3[/SUP], Monto AS[SUP]1[/SUP], Ohmit SE[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza causes significant morbidity and mortality with considerable economic costs, including lost work productivity. Influenza vaccines may reduce the economic burden through primary prevention of influenza and reduction in illness severity.
[h=4]METHODS:[/h] We examined illness severity and work productivity loss among working adults with medically-attended acute respiratory illnesses, and compared outcomes for patients with and without laboratory-confirmed influenza, and by influenza vaccination status among patients with influenza during the 2012-2013 influenza season.
[h=4]RESULTS:[/h] Illnesses laboratory-confirmed as influenza (i.e. Cases) were subjectively assessed as more severe than illnesses not caused by influenza (i.e. Non-Cases) based on multiple measures, including current health status at study enrollment (<7 days from illness onset), and current activity and sleep quality status relative to usual. Influenza Cases reported missing 45% more work hours (20.5 vs. 15.0, P<.001) than Non-Cases, and subjectively assessed their work productivity as impeded to a greater degree (6.0 vs. 5.4, P<.001). Current health status and current activity relative to usual were subjectively assessed as modestly, but significantly, better for vaccinated influenza Cases compared with unvaccinated Cases; however, no significant modifications of sleep quality, missed work hours, or work productivity loss were noted for vaccinated subjects.
[h=4]CONCLUSIONS:[/h] . Influenza illnesses were more severe and resulted in more missed work hours and productivity loss than illnesses not confirmed as influenza. Modest reductions in illness severity for vaccinated influenza cases were observed. These findings highlight the burden of influenza illnesses and illustrate the importance of laboratory-confirmation of influenza outcomes in evaluations of vaccine effectiveness.
? The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
PMID: 26565004 [PubMed - as supplied by publisher]
[h=1]Illness Severity and Work Productivity Loss among Working Adults with Medically-Attended Acute Respiratory Illnesses: US Influenza Vaccine Effectiveness Network 2012-2013.[/h] Petrie JG[SUP]1[/SUP], Cheng C[SUP]1[/SUP], Malosh RE[SUP]1[/SUP], VanWormer JJ[SUP]2[/SUP], Flannery B[SUP]3[/SUP], Zimmerman RK[SUP]4[/SUP], Gaglani M[SUP]5[/SUP], Jackson ML[SUP]6[/SUP], King JP[SUP]2[/SUP], Nowalk MP[SUP]4[/SUP], Benoit J[SUP]6[/SUP], Robertson A[SUP]5[/SUP], Thaker SN[SUP]3[/SUP], Monto AS[SUP]1[/SUP], Ohmit SE[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza causes significant morbidity and mortality with considerable economic costs, including lost work productivity. Influenza vaccines may reduce the economic burden through primary prevention of influenza and reduction in illness severity.
[h=4]METHODS:[/h] We examined illness severity and work productivity loss among working adults with medically-attended acute respiratory illnesses, and compared outcomes for patients with and without laboratory-confirmed influenza, and by influenza vaccination status among patients with influenza during the 2012-2013 influenza season.
[h=4]RESULTS:[/h] Illnesses laboratory-confirmed as influenza (i.e. Cases) were subjectively assessed as more severe than illnesses not caused by influenza (i.e. Non-Cases) based on multiple measures, including current health status at study enrollment (<7 days from illness onset), and current activity and sleep quality status relative to usual. Influenza Cases reported missing 45% more work hours (20.5 vs. 15.0, P<.001) than Non-Cases, and subjectively assessed their work productivity as impeded to a greater degree (6.0 vs. 5.4, P<.001). Current health status and current activity relative to usual were subjectively assessed as modestly, but significantly, better for vaccinated influenza Cases compared with unvaccinated Cases; however, no significant modifications of sleep quality, missed work hours, or work productivity loss were noted for vaccinated subjects.
[h=4]CONCLUSIONS:[/h] . Influenza illnesses were more severe and resulted in more missed work hours and productivity loss than illnesses not confirmed as influenza. Modest reductions in illness severity for vaccinated influenza cases were observed. These findings highlight the burden of influenza illnesses and illustrate the importance of laboratory-confirmation of influenza outcomes in evaluations of vaccine effectiveness.
? The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
PMID: 26565004 [PubMed - as supplied by publisher]