tetano
Editor, Senior Moderator
Immun Inflamm Dis
. 2023 Apr;11(4):e786.
doi: 10.1002/iid3.786. The potential role of scavenger receptor B type I (SR-BI) in SARS-CoV-2 infection
Luay Alkazmi[SUP] 1 [/SUP], Hayder M Al-Kuraishy[SUP] 2 [/SUP], Ali I Al-Gareeb[SUP] 2 [/SUP], Athanasios Alexiou[SUP] 3 4 [/SUP], Marios Papadakis[SUP] 5 [/SUP], Hebatallah M Saad[SUP] 6 [/SUP], Gaber El-Saber Batiha[SUP] 7 [/SUP]
Affiliations
Scavenger receptor type B I (SR-BI), the major receptor for high-density lipoprotein (HDL) mediates the delivery of cholesterol ester and cholesterol from HDL to the cell membrane. SR-BI is implicated as a receptor for entry of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). SR-BI is colocalized with the angiotensin-converting enzyme 2 (ACE2) increasing the binding and affinity of SARS-CoV-2 to ACE2 with subsequent viral internalization. SR-BI regulates lymphocyte proliferation and the release of pro-inflammatory cytokines from activated macrophages and lymphocytes. SR-BI is reduced during COVID-19 due to consumption by SARS-CoV-2 infection. COVID-19-associated inflammatory changes and high angiotensin II (AngII) might be possible causes of repression of SR-BI in SARS-CoV-2 infection. In conclusion, the downregulation of SR-BI in COVID-19 could be due to direct invasion by SARS-CoV-2 or through upregulation of pro-inflammatory cytokines, inflammatory signaling pathways, and high circulating AngII. Reduction of SR-BI in COVID-19 look like ACE2 may provoke COVID-19 severity through exaggeration of the immune response. Further studies are invoked to clarify the potential role of SR-BI in the pathogenesis of COVID-19 that could be protective rather than detrimental.
Keywords: COVID-19; pro-inflammatory cytokines; scavenger receptor type B I.
. 2023 Apr;11(4):e786.
doi: 10.1002/iid3.786. The potential role of scavenger receptor B type I (SR-BI) in SARS-CoV-2 infection
Luay Alkazmi[SUP] 1 [/SUP], Hayder M Al-Kuraishy[SUP] 2 [/SUP], Ali I Al-Gareeb[SUP] 2 [/SUP], Athanasios Alexiou[SUP] 3 4 [/SUP], Marios Papadakis[SUP] 5 [/SUP], Hebatallah M Saad[SUP] 6 [/SUP], Gaber El-Saber Batiha[SUP] 7 [/SUP]
Affiliations
- PMID: 37102664
- DOI: 10.1002/iid3.786
Scavenger receptor type B I (SR-BI), the major receptor for high-density lipoprotein (HDL) mediates the delivery of cholesterol ester and cholesterol from HDL to the cell membrane. SR-BI is implicated as a receptor for entry of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). SR-BI is colocalized with the angiotensin-converting enzyme 2 (ACE2) increasing the binding and affinity of SARS-CoV-2 to ACE2 with subsequent viral internalization. SR-BI regulates lymphocyte proliferation and the release of pro-inflammatory cytokines from activated macrophages and lymphocytes. SR-BI is reduced during COVID-19 due to consumption by SARS-CoV-2 infection. COVID-19-associated inflammatory changes and high angiotensin II (AngII) might be possible causes of repression of SR-BI in SARS-CoV-2 infection. In conclusion, the downregulation of SR-BI in COVID-19 could be due to direct invasion by SARS-CoV-2 or through upregulation of pro-inflammatory cytokines, inflammatory signaling pathways, and high circulating AngII. Reduction of SR-BI in COVID-19 look like ACE2 may provoke COVID-19 severity through exaggeration of the immune response. Further studies are invoked to clarify the potential role of SR-BI in the pathogenesis of COVID-19 that could be protective rather than detrimental.
Keywords: COVID-19; pro-inflammatory cytokines; scavenger receptor type B I.