tetano
Editor, Senior Moderator
Clin Vaccine Immunol. 2014 Jul 2. pii: CVI.00200-14. [Epub ahead of print]
Immunogenicity of the Trivalent Inactivated Influenza Vaccine in Young Children Less Than 4 Years of Age: Focus on Age and Baseline Antibodies.
Mugitani A1, Ito K2, Irie S3, Eto T4, Ishibashi M4, Ohfuji S5, Fukushima W5, Maeda A5, Hirota Y6; the Fukuoka Pediatricians Group for Vaccine Efficacy.
Author information
Abstract
In this study, we assessed the effects of the pre-vaccination titer and age on the immunogenicity of a low dose of influenza vaccine in children less than 4 years of age. A total of 259 children received two vaccine doses (0.1 ml for 0-year-olds and 0.2 ml for children 1 year of age or older) four weeks apart during the 2005/2006 season. The hemaggulutination inhibition antibody titers were measured before vaccination and four weeks after the first and second dose. The geometric mean titer, mean fold rise, seroresponse proportion (≥4-fold rise in titer) and seroprotection proportion (titer≥1:40) were calculated for the pre-vaccination titer and age categories. A multivariate logistic regression analysis was performed using the seroresponse and seroprotection proportions as dependent variables and the pre-vaccination titer and age as explanatory variables. As for the seroresponse against H1 antigen after the first dose, the adjusted odds ratio of the pre-vaccination titers (vs. <1:10) was 2.2 (95% confidence interval: 0.8-5.8) at 1:10 to 1:20 and 0.14 (0.04-0.49) at ≥1:40. The corresponding figures for ages were 0.03 (0.01-0.07) for the 0-year-olds and 0.17 (0.08-0.34) for the 1-year-olds compared with the 2- to 3-year-olds (trend P<0.001). Similar results were also obtained for the H3 and B strains. Significantly elevated odds ratios for seroprotection were observed, with greater pre-vaccination titers and older ages, for all strains. The pre-vaccination titer and age were independently associated with the antibody response in young children. The immune response was weaker in the younger children and those without preexisting immunity.
Copyright ? 2014, American Society for Microbiology. All Rights Reserved.
PMID:
24990904
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24990904
Immunogenicity of the Trivalent Inactivated Influenza Vaccine in Young Children Less Than 4 Years of Age: Focus on Age and Baseline Antibodies.
Mugitani A1, Ito K2, Irie S3, Eto T4, Ishibashi M4, Ohfuji S5, Fukushima W5, Maeda A5, Hirota Y6; the Fukuoka Pediatricians Group for Vaccine Efficacy.
Author information
Abstract
In this study, we assessed the effects of the pre-vaccination titer and age on the immunogenicity of a low dose of influenza vaccine in children less than 4 years of age. A total of 259 children received two vaccine doses (0.1 ml for 0-year-olds and 0.2 ml for children 1 year of age or older) four weeks apart during the 2005/2006 season. The hemaggulutination inhibition antibody titers were measured before vaccination and four weeks after the first and second dose. The geometric mean titer, mean fold rise, seroresponse proportion (≥4-fold rise in titer) and seroprotection proportion (titer≥1:40) were calculated for the pre-vaccination titer and age categories. A multivariate logistic regression analysis was performed using the seroresponse and seroprotection proportions as dependent variables and the pre-vaccination titer and age as explanatory variables. As for the seroresponse against H1 antigen after the first dose, the adjusted odds ratio of the pre-vaccination titers (vs. <1:10) was 2.2 (95% confidence interval: 0.8-5.8) at 1:10 to 1:20 and 0.14 (0.04-0.49) at ≥1:40. The corresponding figures for ages were 0.03 (0.01-0.07) for the 0-year-olds and 0.17 (0.08-0.34) for the 1-year-olds compared with the 2- to 3-year-olds (trend P<0.001). Similar results were also obtained for the H3 and B strains. Significantly elevated odds ratios for seroprotection were observed, with greater pre-vaccination titers and older ages, for all strains. The pre-vaccination titer and age were independently associated with the antibody response in young children. The immune response was weaker in the younger children and those without preexisting immunity.
Copyright ? 2014, American Society for Microbiology. All Rights Reserved.
PMID:
24990904
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24990904